Olson William, Dong Peter, Fleming Michael, Luo Wenqin
Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wiley Interdiscip Rev Dev Biol. 2016 May-Jun;5(3):389-404. doi: 10.1002/wdev.229. Epub 2016 Mar 17.
The mammalian cutaneous low-threshold mechanoreceptors (LTMRs) are a diverse set of primary somatosensory neurons that function to sense external mechanical force. Generally, LTMRs are composed of Aβ-LTMRs, Aδ-LTMRs, and C-LTMRs, which have distinct molecular, physiological, anatomical, and functional features. The specification and wiring of each type of mammalian cutaneous LTMRs is established during development by the interplay of transcription factors with trophic factor signalling. In this review, we summarize the cohort of extrinsic and intrinsic factors generating the complex mammalian cutaneous LTMR circuits that mediate our tactile sensations and behaviors. For further resources related to this article, please visit the WIREs website.
哺乳动物皮肤低阈值机械感受器(LTMRs)是一组多样的初级体感神经元,其功能是感知外部机械力。一般来说,LTMRs由Aβ-LTMRs、Aδ-LTMRs和C-LTMRs组成,它们具有不同的分子、生理、解剖和功能特征。每种类型的哺乳动物皮肤LTMRs的特化和连接在发育过程中通过转录因子与营养因子信号的相互作用而建立。在这篇综述中,我们总结了产生复杂的哺乳动物皮肤LTMR回路的外在和内在因素,这些回路介导我们的触觉感受和行为。有关本文的更多资源,请访问WIREs网站。