• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对合成疟疾抗原AS202.11的天然获得性抗体反应

Naturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11.

作者信息

Nazareth Rebeka, Horumpende Pius, Sonda Tolbert, Ndaro Arnold, Mollel Edson, Paul Eliakim, Athanase Emmanuel, Chilongola Jaffu

机构信息

Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Tanzania.

Kilimanjaro Clinical Research Institute, P.O. Box 2236, Moshi, Tanzania.

出版信息

J Trop Med. 2017;2017:6843701. doi: 10.1155/2017/6843701. Epub 2017 Sep 12.

DOI:10.1155/2017/6843701
PMID:29138641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5613363/
Abstract

BACKGROUND

A major challenge to malaria vaccine development is identification of protective epitopes and respective protective immune responses.

OBJECTIVE

To characterize naturally acquired Immunoglobulin G (IgG) responses to the synthetic peptide AS202.11, a malaria vaccine candidate.

METHODOLOGY

This community based cross-sectional study enrolled 320 participants aged 1 year and above. Demographic information was recorded through interviews. Detection of infection was done by microscopy, malaria rapid diagnostic test, and polymerase chain reaction. ELISA was used to detect IgG antibody. Data was analyzed using STATA.

RESULTS

The overall AS202.11 IgG seropositivity was 78.8% (73.9-82.9). Seropositivity by age categories was ≤12 years [74.3% (67.4-80.2)], 13-40 years [85.3% (76.5-91.1)], and >40 years [82.6% (68.7-91.1)]. Compared to the ≤ 12-year-old group, aORs for the other groups were 2.22 (1.14-4.32), = 0.019, and 1.87 (0.81-4.35), = 0.143, for the 13-40-year-old and >40-year-old groups, respectively. The 13-40-year-old group had more seropositive individuals compared to the ≤ 12-year-old group.

CONCLUSION

We report a high degree of recognition of AS202.11 by IgG elicited by field strains, suggesting its close similarity to native antigens and possible suitability of the peptide as a future malaria vaccine candidate.

摘要

背景

疟疾疫苗研发面临的一个主要挑战是识别保护性表位和相应的保护性免疫反应。

目的

对疟疾候选疫苗合成肽AS202.11的自然获得性免疫球蛋白G（IgG）反应进行特征分析。

方法

这项基于社区的横断面研究纳入了320名1岁及以上的参与者。通过访谈记录人口统计学信息。通过显微镜检查、疟疾快速诊断试验和聚合酶链反应检测感染情况。采用酶联免疫吸附测定法检测IgG抗体。使用STATA软件对数据进行分析。

结果

AS202.11总体IgG血清阳性率为78.8%（73.9 - 82.9）。按年龄组划分的血清阳性率分别为：≤12岁组[74.3%（67.4 - 80.2）]，13 - 40岁组[85.3%（76.5 - 91.1）]，>40岁组[82.6%（68.7 - 91.1）]。与≤12岁组相比，13 - 40岁组和>40岁组的调整后比值比分别为2.22（置信区间：1.14 - 4.32），P = 0.019，以及1.87（置信区间：0.81 - 4.35），P = 0.143。13 - 40岁组血清阳性个体比≤12岁组更多。

结论

我们报告了现场菌株诱导的IgG对AS202.11的高度识别，表明其与天然疟原虫抗原高度相似，且该肽作为未来疟疾候选疫苗具有潜在适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6014/5613363/e39ebe576d68/JTM2017-6843701.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6014/5613363/21a37ecdcf64/JTM2017-6843701.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6014/5613363/e39ebe576d68/JTM2017-6843701.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6014/5613363/21a37ecdcf64/JTM2017-6843701.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6014/5613363/e39ebe576d68/JTM2017-6843701.002.jpg

相似文献

1
Naturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11.对合成疟疾抗原AS202.11的天然获得性抗体反应
J Trop Med. 2017;2017:6843701. doi: 10.1155/2017/6843701. Epub 2017 Sep 12.
2
Humoral immune response to Plasmodium falciparum vaccine candidate GMZ2 and its components in populations naturally exposed to seasonal malaria in Ethiopia.体液免疫对在埃塞俄比亚季节性疟疾流行区自然暴露人群中 PfEMP1 疫苗候选 GMZ2 及其成分的反应。
Malar J. 2013 Feb 5;12:51. doi: 10.1186/1475-2875-12-51.
3
Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort.恶性疟原虫裂殖子表面抗原特异性细胞亲合 IgG 与贝宁出生队列中疟疾感染的控制。
Malar J. 2019 Jun 11;18(1):194. doi: 10.1186/s12936-019-2831-x.
4
Comparative analysis of the profiles of IgG subclass-specific responses to Plasmodium falciparum apical membrane antigen-1 and merozoite surface protein-1 in naturally exposed individuals living in malaria hypoendemic settings, Iran.伊朗疟疾低流行地区自然暴露个体对恶性疟原虫顶端膜抗原1和裂殖子表面蛋白1的IgG亚类特异性反应谱的比较分析。
Malar J. 2015 Feb 5;14:58. doi: 10.1186/s12936-015-0547-0.
5
Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens.钩虫感染和驱虫治疗对 GMZ2 疟疾候选疫苗和成分抗原自然获得性抗体反应的影响。
BMC Infect Dis. 2021 Apr 8;21(1):332. doi: 10.1186/s12879-021-06027-5.
6
Variation in the immune responses against Plasmodium falciparum merozoite surface protein-1 and apical membrane antigen-1 in children residing in the different epidemiological strata of malaria in Cameroon.喀麦隆不同疟疾流行地区儿童对恶性疟原虫裂殖子表面蛋白-1 和顶端膜蛋白-1 免疫应答的差异。
Malar J. 2017 Nov 9;16(1):453. doi: 10.1186/s12936-017-2105-4.
7
Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas.针对GLURP R2、MSP1 2型杂交体和AS202.11的抗体水平以及生活在高度流行地区（布基纳法索）和低度流行地区（加纳）的儿童患疟疾的风险。
Malar J. 2016 Feb 27;15:123. doi: 10.1186/s12936-016-1146-4.
8
Heterogeneity in the acquisition of naturally acquired antibodies to cell-traversal protein for ookinetes and sporozoites (CelTOS) and thrombospondin-related adhesion protein (TRAP) of Plasmodium falciparum in naturally infected patients from unstable malaria areas in Iran.伊朗不稳定疟疾地区自然感染患者中，恶性疟原虫动合子和子孢子细胞穿越蛋白（CelTOS）及血小板反应蛋白相关黏附蛋白（TRAP）天然获得性抗体获取情况的异质性。
Acta Trop. 2019 Feb;190:365-374. doi: 10.1016/j.actatropica.2018.12.014. Epub 2018 Dec 10.
9
An evolutionary approach to identify potentially protective B cell epitopes involved in naturally acquired immunity to malaria and the role of EBA-175 in protection amongst denizens of Bolifamba, Cameroon.一种进化方法，用于鉴定参与疟疾自然获得性免疫的潜在保护性B细胞表位以及EBA-175在喀麦隆博利方巴居民的保护作用。
Malar J. 2016 May 20;15(1):281. doi: 10.1186/s12936-016-1337-z.
10
IgG antibodies to synthetic GPI are biomarkers of immune-status to both Plasmodium falciparum and Plasmodium vivax malaria in young children.针对合成糖基磷脂酰肌醇的 IgG 抗体是婴幼儿对恶性疟原虫和间日疟原虫疟疾免疫状况的生物标志物。
Malar J. 2017 Sep 25;16(1):386. doi: 10.1186/s12936-017-2042-2.

本文引用的文献

1
Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas.针对GLURP R2、MSP1 2型杂交体和AS202.11的抗体水平以及生活在高度流行地区（布基纳法索）和低度流行地区（加纳）的儿童患疟疾的风险。
Malar J. 2016 Feb 27;15:123. doi: 10.1186/s12936-016-1146-4.
2
Spread of artemisinin resistance in Plasmodium falciparum malaria.疟原虫青蒿素耐药性的传播。
N Engl J Med. 2014 Jul 31;371(5):411-23. doi: 10.1056/NEJMoa1314981.
3
Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children.
Fc 伽马受体 3B（FCGR3B-c.233C＞A-rs5030738）多态性改变了加纳儿童疟疾特异性抗体的保护作用。
J Infect Dis. 2014 Jan 15;209(2):285-9. doi: 10.1093/infdis/jit422. Epub 2013 Aug 9.
4
Multiple-insecticide resistance in Anopheles gambiae mosquitoes, Southern Côte d'Ivoire.冈比亚按蚊对多种杀虫剂的抗药性，科特迪瓦南部。
Emerg Infect Dis. 2012 Sep;18(9):1508-11. doi: 10.3201/eid1809.120262.
5
A major genome region underlying artemisinin resistance in malaria.一个主要的基因组区域是导致疟疾对青蒿素产生抗药性的原因。
Science. 2012 Apr 6;336(6077):79-82. doi: 10.1126/science.1215966.
6
Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte.超高分辨率解析疟原虫入侵人类红细胞过程中的协调事件。
Cell Host Microbe. 2011 Jan 20;9(1):9-20. doi: 10.1016/j.chom.2010.12.003.
7
The future for blood-stage vaccines against malaria.疟疾血液阶段疫苗的未来。
Immunol Cell Biol. 2009 Jul;87(5):377-90. doi: 10.1038/icb.2009.27. Epub 2009 May 5.
8
Evidence of artemisinin-resistant malaria in western Cambodia.柬埔寨西部出现青蒿素耐药性疟疾的证据。
N Engl J Med. 2008 Dec 11;359(24):2619-20. doi: 10.1056/NEJMc0805011. Epub 2008 Dec 8.
9
Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.用Montanide ISA 51配制的疟疾传播阻断候选疫苗Pfs25和Pvs25的1期试验
PLoS One. 2008 Jul 9;3(7):e2636. doi: 10.1371/journal.pone.0002636.
10
Longitudinal analyses of immune responses to Plasmodium falciparum derived peptides corresponding to novel blood stage antigens in coastal Kenya.对肯尼亚沿海地区与新型血液阶段抗原相对应的恶性疟原虫衍生肽的免疫反应的纵向分析。
Vaccine. 2008 Apr 7;26(16):1963-71. doi: 10.1016/j.vaccine.2008.02.020. Epub 2008 Feb 26.