Cookson W O, Craddock C F, Benson M K, Durham S R
Osler Chest Unit, Churchill Hospital, Headington, Oxford, United Kingdom.
Am Rev Respir Dis. 1989 Feb;139(2):458-62. doi: 10.1164/ajrccm/139.2.458.
Peripheral eosinophil counts were measured at intervals before and after control and allergen inhalation in 14 asthmatic subjects. A relative fall in eosinophil counts was noted 9 h after allergen challenge, in contrast to the diurnal increase seen on the control day (p = 0.005). This fall in eosinophil count correlated strongly with the magnitude of the late asthmatic response (r = -0.72, p = 0.003) and with the changes in bronchial responsiveness to histamine at 3 and 24 h after allergen was given (r = 0.54, p = 0.044 and r = 0.82, p less than 0.001, respectively). The findings demonstrate eosinophil kinetics are related to the occurrence of late-phase reactions and to the associated worsening of bronchial hyperreactivity.
在14名哮喘患者中，在吸入对照物和变应原前后的不同时间点测量外周血嗜酸性粒细胞计数。变应原激发后9小时观察到嗜酸性粒细胞计数相对下降，这与对照日观察到的昼夜增加形成对比（p = 0.005）。嗜酸性粒细胞计数的下降与迟发性哮喘反应的程度密切相关（r = -0.72，p = 0.003），并与给予变应原后3小时和24小时支气管对组胺反应性的变化相关（r = 0.54，p = 0.044和r = 0.82，p分别小于0.001）。这些发现表明嗜酸性粒细胞动力学与迟发性反应的发生以及支气管高反应性的相关恶化有关。
