Santens Patrick
Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
Acta Neurol Belg. 2018 Mar;118(1):13-19. doi: 10.1007/s13760-017-0862-z. Epub 2017 Nov 14.
The neurophysiology of gait is complex and involves numerous structures in the central nervous system. Gait disorders occur frequently in Parkinson's disease (PD), and their management may become cumbersome, especially in the more advanced stages. Neuromodulatory treatments, including deep brain stimulation, cortical stimulation and spinal cord stimulation, are reviewed with respect to their effectiveness to improve gait in PD patients. Although positive effects have been reported for all of these procedures, many issues remain in view of methodological heterogeneity, variability in outcome measures and sample size. Gait in PD remains a difficult issue with a tremendous impact on quality of life, for which future research is badly needed.
步态的神经生理学很复杂，涉及中枢神经系统中的众多结构。步态障碍在帕金森病（PD）中经常出现，其治疗可能会变得很麻烦，尤其是在疾病的晚期阶段。本文综述了神经调节治疗，包括深部脑刺激、皮层刺激和脊髓刺激，以探讨它们改善帕金森病患者步态的有效性。尽管所有这些治疗方法都报告了积极效果，但由于方法的异质性、结果测量的变异性和样本量的问题，仍存在许多问题。帕金森病患者的步态仍然是一个难题，对生活质量有巨大影响，因此急需未来的研究。
