Lozano Andres M, Snyder Brian J
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, 399 Bathurst Street WW 4-447, Toronto, ON, M5T2S8, Canada.
J Neurol. 2008 Aug;255 Suppl 4:30-1. doi: 10.1007/s00415-008-4005-6.
The cardinal motor manifestation of Parkinson's disease (PD) is being treated with greater and greater efficacy with both newer medications as well as both subthalamic nucleus (STN) and globus pallidus internus (GPI) deep brain stimulation (DBS). The burden of disease is shifting towards the non-dopaminergic disease manifestations including gait and posture. Based on evidence in the literature and in animal models, recent trials are underway to examine the effects of pedunculopontine nucleus DBS on the treatment of parkinsonian gait disorder. We review the rationale behind this treatment and the status of the current trials.
帕金森病(PD)主要的运动表现正通过使用更新的药物以及丘脑底核(STN)和苍白球内侧部(GPI)深部脑刺激(DBS)得到越来越有效的治疗。疾病负担正转向包括步态和姿势在内的非多巴胺能疾病表现。基于文献和动物模型中的证据,目前正在进行试验以研究脚桥核DBS对帕金森步态障碍治疗的效果。我们回顾了这种治疗背后的基本原理以及当前试验的进展情况。