Rosso Marinela, Prgomet Drago, Marjanović Ksenija, Pušeljić Silvija, Tićac Robert, Mihaljević Ivan
Coll Antropol. 2016 Jun;40(2):123-6.
The aim of this study was to determine the long term histopathologic changes in tracheal mucosa after a total laryngectomy , and to find out the relationship between the progression of histopathologic changes in tracheal mucosa and the duration of breathing through the tracheostomy. Tracheal mucosal biopsies were taken from a total of 35 patients, of both sexes, who underwent a total laryngectomy for laryngeal carcinoma at least one year prior. Histologic specimens of tracheal mucosa were stained with hematoxylin and eosin and examined under light microscopy. Almost all of the patients demonstrated histopathologic changes or abnormalities. Based on the results, histological findings were grouped into seven categories: normal respiratory epithelium, mild, moderate and advanced basal cell hyperplasia, squamous metaplasia, and slight and moderate and dysplasia. The time elapsed since surgery was calculated for each histopathological change separately. In laryngeal carcinoma patients, after a total laryngectomy histopathologic changes occur in tracheal mucosa. The mildest histopathological changes are found in the patients who had a longer period between the operation and the examination.
本研究的目的是确定全喉切除术后气管黏膜的长期组织病理学变化，并找出气管黏膜组织病理学变化的进展与气管切开术后呼吸时间之间的关系。共对35例患者进行了气管黏膜活检，这些患者均为至少在一年前因喉癌接受全喉切除术的男女患者。气管黏膜组织学标本用苏木精和伊红染色，并在光学显微镜下检查。几乎所有患者均表现出组织病理学变化或异常。根据结果，组织学发现分为七类：正常呼吸上皮、轻度、中度和重度基底细胞增生、鳞状化生以及轻度、中度和发育异常。分别计算每种组织病理学变化自手术以来经过的时间。在喉癌患者中，全喉切除术后气管黏膜会发生组织病理学变化。在手术与检查之间间隔时间较长的患者中发现的组织病理学变化最为轻微。
