Lewanczuk R Z, Wang J, Zhang Z R, Pang P K
Division of Endocrinology, University of Alberta, Edmonton, Canada.
Am J Hypertens. 1989 Jan;2(1):26-31.
Previous studies have described the presence of humoral hypertensive factors in spontaneously hypertensive rats (SHR). Other studies have described factors that increase calcium uptake in vascular tissue. In this study, we attempted to confirm, and thereby correlate, the presence of both types of factors in SHR plasma. Intravenous infusion or bolus administration of dialyzed SHR plasma consistently induced an increase in blood pressure in normotensive rats. This hypertensive response was somewhat delayed, with peak blood pressures occurring 45 minutes after bolus administration and 90 minutes after infusion of SHR plasma. Spontaneously hypertensive rat plasma also increased 45Ca uptake in isolated normotensive rat tail arteries in a dose-dependent manner, with a time course similar to that for the hypertensive response to bolus administration. These findings suggest, therefore, that a substance exists in SHR plasma that can increase intracellular calcium in vascular tissues and thereby increase blood pressure.
先前的研究已经描述了自发性高血压大鼠（SHR）体内存在体液性高血压因子。其他研究也描述了一些可增加血管组织钙摄取的因子。在本研究中，我们试图证实SHR血浆中这两种类型因子的存在，并建立它们之间的关联。向正常血压大鼠静脉输注或推注透析后的SHR血浆，均持续导致血压升高。这种高血压反应有所延迟，推注SHR血浆后45分钟出现血压峰值，输注后90分钟出现血压峰值。自发性高血压大鼠血浆还以剂量依赖的方式增加了离体正常血压大鼠尾动脉对45Ca的摄取，其时间进程与推注给药后高血压反应的时间进程相似。因此，这些发现表明，SHR血浆中存在一种物质，它可以增加血管组织中的细胞内钙，从而升高血压。
