Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan.
Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan; Department of Biochemistry, Jinnah Medical & Dental College, Karachi, Pakistan.
Neuroscience. 2018 Feb 1;370:121-129. doi: 10.1016/j.neuroscience.2017.11.014. Epub 2017 Nov 12.
Memory functions can be considerably affected by various life events and stress has shown to be a chief regulator. Different stress patterns have distinct effects on the overall functioning of the brain. Stress provokes inflammation not only in the periphery but also in the brain. Neuroinflammation causes alterations in neuronal structure and function, which eventually progress to the development of neurodegenerative diseases. Inflammatory reactions are modulated through communication between the nervous, endocrine and immune systems. An excessive release of stress hormones and changes in the neurotransmission system may cause cognitive impairments. The present study investigated dissimilar stress-related memory deficits and their diminution by non-steroidal anti-inflammatory drugs (NSAIDs). Treatment with cyclooxygenase inhibitors, which inhibit prostaglandin synthesis, has enhanced memory functions in a number of neuroinflammatory states. In this study, rats were exposed to a series of dissimilar stressors and behavioral parameters for depression and memory functions were examined. Corticosterone, serotonin (5-HT) and dopamine (DA) levels were also estimated. Results from the forced swim test, elevated plus maze test and Morris water maze test showed significant effects of NSAIDs. A significant decrease in plasma corticosterone and increased DA and 5-HT levels were observed in NSAID-treated dissimilar-stressed rats. This study demonstrates the therapeutic potential of NSAIDs for dissimilar stress-induced depressive behaviors and impaired memory functions and related hormonal and neurochemical changes in the rat brain.
记忆功能可能会受到各种生活事件的显著影响，而压力被证明是主要的调节因素。不同的压力模式对大脑的整体功能有不同的影响。压力不仅会引发外周炎症，还会引发大脑炎症。神经炎症会导致神经元结构和功能的改变，最终发展为神经退行性疾病。炎症反应通过神经系统、内分泌系统和免疫系统之间的通讯进行调节。应激激素的过度释放和神经递质传递系统的改变可能导致认知障碍。本研究探讨了不同的与压力相关的记忆缺陷及其通过非甾体抗炎药（NSAIDs）的减轻情况。抑制前列腺素合成的环氧化酶抑制剂的治疗在许多神经炎症状态下增强了记忆功能。在这项研究中，大鼠暴露于一系列不同的应激源中，检测了抑郁和记忆功能的行为参数。还估计了皮质酮、血清素（5-HT）和多巴胺（DA）的水平。强迫游泳试验、高架十字迷宫试验和 Morris 水迷宫试验的结果显示 NSAIDs 有显著效果。在接受 NSAIDs 治疗的不同应激大鼠中，血浆皮质酮显著降低，DA 和 5-HT 水平升高。这项研究表明 NSAIDs 具有治疗不同应激引起的抑郁行为和受损记忆功能以及相关的大鼠大脑激素和神经化学变化的潜力。
