Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
Department of Biomedical Engineering, NED University of Engineering and Technology, Karachi 75270, Pakistan.
Medicina (Kaunas). 2020 Jul 14;56(7):350. doi: 10.3390/medicina56070350.
Elevated oxidative stress has been shown to play an important role in the diagnosis and prognosis of stress and memory-related complications. () has been reported to have various biological and antioxidant properties. We intended to evaluate the effect of peel on single immobilization stress-induced behavioral deficits and memory changes in rats. peel (2000 mg/kg/day, orally) was administered to control and immobilize stressed animals for 4 weeks. Anxiolytic, antidepressant, and memory-enhancing effects of were observed in both unstressed and stressed animals. Lipid peroxidation was decreased while antioxidant enzymes were increased in both unstressed and stressed animals. Acetylcholine level was increased while acetylcholinesterase activity was decreased in both treated unstressed and stressed rats. There was also an improvement in memory function. Serotonin neurotransmission was also regulated in treated rats following immobilization stress with anxiolytic and anti-depressive effects. Based on the current study, it is suggested that has strong antioxidant properties and may be beneficial as dietary supplementation in stress and memory-related conditions.
氧化应激升高已被证明在应激和记忆相关并发症的诊断和预后中起着重要作用。（）具有多种生物和抗氧化特性。我们旨在评估 果皮对单束缚应激诱导的大鼠行为缺陷和记忆变化的影响。果皮（2000mg/kg/天，口服）给予对照和束缚应激动物 4 周。在未应激和应激动物中均观察到 具有抗焦虑、抗抑郁和增强记忆的作用。在未应激和应激动物中，脂质过氧化作用降低，抗氧化酶活性增加。乙酰胆碱水平升高，而乙酰胆碱酯酶活性在未应激和应激大鼠中均降低。记忆功能也得到改善。5-羟色胺神经递质也在束缚应激后得到调节，具有抗焦虑和抗抑郁作用。基于目前的研究，建议 具有很强的抗氧化特性，可作为膳食补充剂用于应激和记忆相关疾病。
