Behavioral and Biochemical Effects of Following Single Immobilization Stress on Rats.

Elevated oxidative stress has been shown to play an important role in the diagnosis and prognosis of stress and memory-related complications. () has been reported to have various biological and antioxidant properties. We intended to evaluate the effect of peel on single immobilization stress-induced behavioral deficits and memory changes in rats. peel (2000 mg/kg/day, orally) was administered to control and immobilize stressed animals for 4 weeks. Anxiolytic, antidepressant, and memory-enhancing effects of were observed in both unstressed and stressed animals. Lipid peroxidation was decreased while antioxidant enzymes were increased in both unstressed and stressed animals. Acetylcholine level was increased while acetylcholinesterase activity was decreased in both treated unstressed and stressed rats. There was also an improvement in memory function. Serotonin neurotransmission was also regulated in treated rats following immobilization stress with anxiolytic and anti-depressive effects. Based on the current study, it is suggested that has strong antioxidant properties and may be beneficial as dietary supplementation in stress and memory-related conditions.