麻醉剂同系物对乌贼巨大轴突静息钾电导的影响。

The effects of homologous series of anaesthetics on a resting potassium conductance of the squid giant axon.

作者信息

Elliott A A, Elliott J R, Haydon D A

机构信息

Department of Anatomy and Physiology, University, Dundee, U.K.

出版信息

Biochim Biophys Acta. 1989 Jan 30;978(2):337-40. doi: 10.1016/0005-2736(89)90134-x.

DOI:10.1016/0005-2736(89)90134-x

PMID:2914145

Abstract

The effects of n-alkanes (n-pentane to n-octane), n-alkanols (n-pentanol to n-undecanol) and two carboxylic esters (methyl pentanoate and methyl octanoate) on the conductance of squid giant axons in a high potassium, zero sodium bathing solution have been examined. Sodium and delayed rectifier potassium channels were as far as possible pharmacologically blocked. A substantial fraction of the measured conductance is attributed to a recently-described, voltage-independent, potassium channel. Anaesthetics block this channel but its sensitivity is markedly different from those of other squid axon ion channels.

摘要

研究了正构烷烃（正戊烷至正辛烷）、正构烷醇（正戊醇至正十一醇）以及两种羧酸酯（戊酸甲酯和辛酸甲酯）对处于高钾、零钠浴液中的乌贼巨大轴突电导率的影响。尽可能在药理学上阻断钠通道和延迟整流钾通道。所测得的电导率中有很大一部分归因于最近描述的一种电压非依赖性钾通道。麻醉剂会阻断该通道，但其敏感性与乌贼轴突的其他离子通道明显不同。