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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Elliott J R, Elliott A A, Harper A A, Winpenny J P

Department of Anatomy and Physiology, Old Medical School, The University Dundee, Scotland.

Gen Pharmacol. 1992 Nov;23(6):1005-11. doi: 10.1016/0306-3623(92)90278-r.

The effects of clinical inhalation anaesthetics, such as halothane and methoxyflurane, and "model" anaesthetics, such as hydrocarbons and n-alkanols, on neuronal sodium and potassium channels are reviewed. 2. Lipid-based mechanisms for the actions of anaesthetics on the gating parameters of squid axon sodium and delayed rectifier potassium currents are considered in conjunction with evidence of more specific effects in other preparations, notably a fast inactivating potassium current in Helix neurones and a voltage-gated sodium current in rat dorsal root ganglion neurones. 3. The proconvulsant actions of some inhalation anaesthetics are discussed in relation to the induction of spontaneous firing of action potentials in the squid giant axon.

综述了临床吸入麻醉药（如氟烷和甲氧氟烷）以及“模型”麻醉药（如碳氢化合物和正链烷醇）对神经元钠通道和钾通道的影响。2. 结合其他制剂中更具体效应的证据，特别是海兔神经元中的快速失活钾电流和大鼠背根神经节神经元中的电压门控钠电流，探讨了基于脂质的麻醉药作用机制对鱿鱼轴突钠电流和延迟整流钾电流门控参数的影响。3. 讨论了一些吸入麻醉药的促惊厥作用与鱿鱼巨大轴突中动作电位自发放电诱导的关系。

Elliott J R, Elliott A A, Harper A A, Winpenny J P

Department of Anatomy and Physiology, Old Medical School, The University Dundee, Scotland.

Gen Pharmacol. 1992 Nov;23(6):1005-11. doi: 10.1016/0306-3623(92)90278-r.

The effects of clinical inhalation anaesthetics, such as halothane and methoxyflurane, and "model" anaesthetics, such as hydrocarbons and n-alkanols, on neuronal sodium and potassium channels are reviewed. 2. Lipid-based mechanisms for the actions of anaesthetics on the gating parameters of squid axon sodium and delayed rectifier potassium currents are considered in conjunction with evidence of more specific effects in other preparations, notably a fast inactivating potassium current in Helix neurones and a voltage-gated sodium current in rat dorsal root ganglion neurones. 3. The proconvulsant actions of some inhalation anaesthetics are discussed in relation to the induction of spontaneous firing of action potentials in the squid giant axon.

综述了临床吸入麻醉药（如氟烷和甲氧氟烷）以及“模型”麻醉药（如碳氢化合物和正链烷醇）对神经元钠通道和钾通道的影响。2. 结合其他制剂中更具体效应的证据，特别是海兔神经元中的快速失活钾电流和大鼠背根神经节神经元中的电压门控钠电流，探讨了基于脂质的麻醉药作用机制对鱿鱼轴突钠电流和延迟整流钾电流门控参数的影响。3. 讨论了一些吸入麻醉药的促惊厥作用与鱿鱼巨大轴突中动作电位自发放电诱导的关系。