Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital.
Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University.
Magn Reson Med Sci. 2018 Jul 10;17(3):223-230. doi: 10.2463/mrms.mp.2017-0094. Epub 2017 Nov 16.
The feasibility of steady-state sequences for O imaging was evaluated based on a kinetic analysis of the brain parenchyma and cerebrospinal fluid (CSF).
The institutional review board approved this prospective study with written informed consent. Dynamic 2D or 3D steady-state sequences were performed in five and nine participants, respectively, with different parameters using a 3T scanner. During two consecutive dynamic scans, saline was intravenously administered for control purposes in the first scan, and 20% O-labeled water (1 mL/Kg) was administered in the second scan. Signal changes relative to the baseline were calculated, and kinetic analyses of the curves were conducted for all voxels. Region of interest analysis was performed in the brain parenchyma, choroid plexus, and CSF spaces.
Average signal drops were significantly larger in the O group than in the controls for most of the imaging parameters. Different kinetic parameters were observed between the brain parenchyma and CSF spaces. Average and maximum signal drops were significantly larger in the CSF spaces and choroid plexus than in the brain parenchyma. Bolus arrival, time to peak, and the first moment of dynamic curves of O in the CSF space were delayed compared to that in the brain parenchyma. Significant differences between the ventricle and subarachnoid space were also noted.
Steady-state sequences are feasible for indirect O imaging with reasonable temporal resolution; this result is potentially important for the analysis of water kinetics and aquaporin function for several disorders.
基于脑实质和脑脊液（CSF）的动力学分析，评估 O 成像稳态序列的可行性。
本前瞻性研究经机构审查委员会批准，并获得了书面知情同意。使用 3T 扫描仪，分别在五名和九名参与者中使用不同参数进行二维或三维稳态序列。在两次连续动态扫描中，第一次扫描时静脉内注射生理盐水用于对照，第二次扫描时给予 20% O 标记水（1mL/Kg）。计算与基线相比的信号变化，并对所有体素进行曲线动力学分析。在脑实质、脉络丛和 CSF 空间进行感兴趣区分析。
对于大多数成像参数，O 组的平均信号下降明显大于对照组。脑实质和 CSF 空间之间观察到不同的动力学参数。CSF 空间和脉络丛的平均和最大信号下降明显大于脑实质。与脑实质相比，O 在 CSF 空间中的造影剂到达时间、达峰时间和动态曲线的第一时间延迟。还注意到脑室和蛛网膜下腔之间的显著差异。
稳态序列对于间接 O 成像具有合理的时间分辨率是可行的；这一结果对于分析几种疾病的水动力学和水通道蛋白功能具有重要意义。
