Kiorpes A L, Mirsky M L, MacWilliams P S, Bäckström L R, Collins M T
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
Can J Vet Res. 1989 Jan;53(1):95-9.
Blood gas and hematological responses to acute, mild Actinobacillus pleuropneumoniae infection of growing pigs was studied. Six pigs (average weight 10.1 kg) were experimentally infected intranasally with A. pleuropneumoniae serotype 5. Four pigs served as controls. Rectal temperatures and arterial blood for gas analysis and hematology were taken at 0, 8, 16, 24, 48 and 72 h postinfection. All infected pigs became febrile showing clinical signs typical of mild to moderate porcine pleuropneumonia; controls remained asymptomatic. Neutrophilia with bands and lymphopenia were observed only in infected pigs. Arterial partial pressures of O2 and CO2, and pH did not change in infected pigs. All pigs were killed after 72 h, and lungs were examined and cultured. Gross and microscopic lesions consistent with porcine pleuropneumonia were seen in 3/6 and 5/6 infected lungs, respectively. Control lungs were grossly normal with no histological evidence of pleuropneumonia. We conclude that in mild, acute porcine pleuropneumonia as established experimentally, a leukogram typical of acute inflammation and stress is seen; however, hypoxemia and alveolar hypoventilation are not features of this form of the disease.
研究了生长猪急性轻度胸膜肺炎放线杆菌感染后的血气和血液学反应。6头猪（平均体重10.1千克）经鼻内实验性感染胸膜肺炎放线杆菌血清型5。4头猪作为对照。在感染后0、8、16、24、48和72小时测量直肠温度，并采集动脉血进行气体分析和血液学检查。所有感染猪均发热，表现出轻度至中度猪胸膜肺炎的典型临床症状；对照猪无症状。仅在感染猪中观察到中性粒细胞增多伴杆状核细胞增多和淋巴细胞减少。感染猪的动脉血氧分压、二氧化碳分压和pH值未发生变化。72小时后处死所有猪，并检查和培养肺部。在6例感染猪中，分别有3例和5例肺脏出现与猪胸膜肺炎一致的大体和显微镜下病变。对照猪的肺脏大体正常，无胸膜肺炎的组织学证据。我们得出结论，在实验性建立的轻度急性猪胸膜肺炎中，可见典型的急性炎症和应激白细胞象；然而，低氧血症和肺泡通气不足不是这种疾病形式的特征。
