Kiranmayee Donthu, Kavya Kothapalli, Himabindu Yalamanchali, Sriharibabu Manne, Madhuri Gadi Leela Jaya, Venu Swargam
Department of Obstetrics and Gynaecology, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh, India.
Department of Medicine, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh, India.
J Hum Reprod Sci. 2017 Jul-Sep;10(3):167-172. doi: 10.4103/jhrs.JHRS_108_16.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women and is associated with both reproductive and metabolic abnormalities. Recent studies have demonstrated an early onset of abnormal cardiovascular risk profile in women with PCOS. Abnormal lipid profile patterns are common in women with PCOS, and these abnormalities are not uniform in all populations. Anthropometry is a simple and commonly used research tool for assessing metabolic risk in women with PCOS. Therefore, this study examined the correlations between anthropometric parameters and lipid profile in women with PCOS.
The objectives of the study were (1) To study the anthropometric profile of women with PCOS, (2) To examine the lipid profile pattern of these women with PCOS and (3) To see whether there exists any correlation between these anthropometric parameters and lipid profile.
This observational cross-sectional study examined anthropometry and lipid profile in 86 married women with PCOS in the age group of 18-35 years and correlated them by using Pearson's correlation coefficient.
More than 80% of the women with PCOS demonstrated abnormal anthropometric parameters, and in more than 70% women, lipid abnormalities such as low levels of high-density lipoprotein (HDL) cholesterol and high levels of triglycerides and low-density lipoprotein cholesterol were observed. Significant positive correlations were seen between body mass index (BMI) and triglycerides ( ≤ 0.001) and waist circumference (WC) and triglycerides ( ≤ 0.029). Negative correlations were observed between BMI and HDL cholesterol ( ≤ 0.013).
This study revealed that BMI and WC are the most important anthropometric parameters correlated to dyslipidemia in the south Indian women with PCOS.
多囊卵巢综合征(PCOS)是育龄女性中最常见的内分泌疾病,与生殖和代谢异常均相关。近期研究表明,PCOS女性心血管风险异常特征出现较早。PCOS女性中脂质谱异常模式常见,且这些异常在所有人群中并不一致。人体测量学是评估PCOS女性代谢风险的一种简单且常用的研究工具。因此,本研究探讨了PCOS女性人体测量参数与脂质谱之间的相关性。
本研究的目的为:(1)研究PCOS女性的人体测量特征;(2)检测这些PCOS女性的脂质谱模式;(3)观察这些人体测量参数与脂质谱之间是否存在相关性。
本观察性横断面研究检测了86名年龄在18 - 35岁的已婚PCOS女性的人体测量学指标和脂质谱,并使用Pearson相关系数对它们进行相关性分析。
超过80%的PCOS女性表现出异常的人体测量参数,超过70%的女性存在脂质异常,如高密度脂蛋白(HDL)胆固醇水平低、甘油三酯和低密度脂蛋白胆固醇水平高。体重指数(BMI)与甘油三酯(≤0.001)以及腰围(WC)与甘油三酯(≤0.029)之间存在显著正相关。BMI与HDL胆固醇之间存在负相关(≤0.013)。
本研究表明,在南印度PCOS女性中,BMI和WC是与血脂异常相关的最重要人体测量参数。