Mehra Tanuja, Sharma Sonali, Zahra Tasneem, Jangir Sapna, Gupta Barkha
Department of Biochemistry, RUHS College of Medical Sciences, Sector-11, Kumbha Marg, Pratap Nagar, Jaipur, Rajasthan 302033 India.
Department of Obstetrics and Gynaecology, RUHS College of Medical Sciences, Sector-11, Kumbha Marg, Pratap Nagar, Jaipur, Rajasthan India.
Indian J Clin Biochem. 2023 Apr;38(2):231-241. doi: 10.1007/s12291-022-01042-y. Epub 2022 May 5.
This was a prospective observational study, conducted at a tertiary care health centre in Rajasthan. A total of 68 women with PCOS (Rotterdam criteria) attending OPD at Department of Obstetrics and Gynecology qualified as per inclusion and exclusion criteria were included in the study. Each participant was examined for anthropometric and biochemical parameters. The largest phenotypic group was phenotype A, (41.17%); followed by B (26.47%); C (20.58%), and D (P + O) phenotypes (11.76%). Hyperandrogenic phenotypes (A, B, C), had significantly higher prevalence of deranged serum glucose (fasting and postprandial), lipid profile and serum TSH than normoandrogenic phenotype D. BMI was strongly correlated with anthropometric ( < 0.001) and biochemical parameters ( < 0.05) in phenotype A among four phenotypes of PCOS. Phenotype A was the most common form of PCOS and a strong correlation of BMI with waist circumference (WC), dyslipidemia and Sub-clinical hypothyroidism (SCH) was observed in women of this phenotype of PCOS. These results indicate that phenotype A is at increased risk of CVD and diabetes and phenotype D has least metabolic risks.
这是一项前瞻性观察性研究,在拉贾斯坦邦的一家三级医疗保健中心进行。共有68名符合鹿特丹标准的多囊卵巢综合征(PCOS)女性在妇产科门诊就诊,根据纳入和排除标准合格后纳入研究。对每位参与者进行人体测量和生化参数检查。最大的表型组是A表型(41.17%);其次是B表型(26.47%);C表型(20.58%),以及D表型(P+O)(11.76%)。高雄激素表型(A、B、C)的血清葡萄糖(空腹和餐后)、血脂谱和血清促甲状腺激素紊乱的患病率显著高于正常雄激素表型D。在PCOS的四种表型中,A表型的体重指数(BMI)与人体测量参数(<0.001)和生化参数(<0.05)密切相关。A表型是PCOS最常见的形式,在这种PCOS表型的女性中观察到BMI与腰围(WC)、血脂异常和亚临床甲状腺功能减退(SCH)密切相关。这些结果表明,A表型患心血管疾病和糖尿病的风险增加,而D表型的代谢风险最低。