Kardos T F, Maygarden S J, Blumberg A K, Wakely P E, Frable W J
Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Cancer. 1989 Feb 15;63(4):703-7. doi: 10.1002/1097-0142(19890215)63:4<703::aid-cncr2820630418>3.0.co;2-g.
To determine the effectiveness of fine needle aspiration (FNA) of the lymph node in the management of young patients with peripheral lymphadenopathy, all patients 30 years of age and under who had a lymph node aspirate and who then had subsequent excisional biopsy, autopsy, or clinical follow-up for a minimum of one year were examined. One hundred twenty-seven aspirates from one hundred twenty-six patients fulfilled the criteria of the study. Diagnoses of eighty-three benign and thirty-seven malignant lymphadenopathies were confirmed. There were three false negative and four false positive diagnoses. Sensitivity, specificity, and positive and negative predictive values were 0.93, 0.95, 0.90, and 0.97%, respectively. Of the one hundred twenty-six patients, twenty-five had a previous history of malignancy. Results of aspiration biopsy in this group were examined to determine FNA ability to predict recurrent disease. In this group the sensitivity, specificity and positive and negative predictive values were 0.95, 0.80, 0.95, and 0.80 respectively. Finally, the group of patients with clinically suspicious primary lymphadenopathy without an antecedent history of malignancy were examined to determine the effectiveness of the technique for selecting patients for surgical biopsy. This group included a total of one hundred two patients. Sensitivity, specificity, and positive and negative predictive values were 0.93, 0.96, 0.90, and 0.97, respectively. Based on the data from this retrospective study, we conclude that fine needle aspiration provides a useful tool in the management of young patients with peripheral lymphadenopathy, both in monitoring recurrent disease and in triaging patients with clinically suspicious primary lymphadenopathy to determined the next appropriate step in management.
为确定细针穿刺抽吸（FNA）淋巴结在年轻外周淋巴结病患者管理中的有效性，对所有30岁及以下、进行了淋巴结抽吸且随后接受了切除活检、尸检或至少一年临床随访的患者进行了检查。126例患者的127次抽吸符合研究标准。确诊83例良性和37例恶性淋巴结病。有3例假阴性和4例假阳性诊断。敏感性、特异性、阳性和阴性预测值分别为0.93、0.95、0.90和0.97%。126例患者中，25例有恶性肿瘤病史。检查该组患者的穿刺活检结果以确定FNA预测复发疾病的能力。该组的敏感性、特异性、阳性和阴性预测值分别为0.95、0.80、0.95和0.80。最后，对无恶性肿瘤既往史的临床可疑原发性淋巴结病患者组进行检查，以确定该技术在选择手术活检患者方面的有效性。该组共有102例患者。敏感性、特异性、阳性和阴性预测值分别为0.93、0.96、0.90和0.97。基于这项回顾性研究的数据，我们得出结论，细针穿刺抽吸在外周淋巴结病年轻患者的管理中提供了一种有用的工具，无论是在监测复发疾病还是在对临床可疑原发性淋巴结病患者进行分类以确定下一步合适的管理步骤方面。
