Mobley D L, Wakely P E, Frable M A
Department of Otolaryngology, Head and Neck Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Laryngoscope. 1991 May;101(5):469-72. doi: 10.1288/00005537-199105000-00004.
Fine-needle aspiration biopsy cytology is widely used to screen masses in adults. The authors present a series of 89 fine-needle aspiration biopsies performed between January 1973 and December 1988 on 86 pediatric patients with clinically significant head and neck masses. All fine-needle aspiration diagnoses were confirmed by subsequent surgical biopsy, autopsy, or clinical follow-up for a minimum of 18 months. Of 21 tumors identified, 19 were malignant. Of the 89 aspirations performed, 67 required no subsequent surgical biopsy. In 11 of these cases, metastatic or recurrent tumor was diagnosed and appropriate therapy instituted. Fifteen of the 89 aspirates revealed previously undiagnosed tumors requiring surgical intervention. One false-negative and two false-positive results were obtained. No radical treatment resulted from the false-positive diagnoses, and no patient delay in treatment occurred because of the false-negative result. The sensitivity was 94.4%, and the specificity was 97.1%. The usefulness and cost-effectiveness of fine-needle aspiration is stressed.
细针穿刺活检细胞学检查广泛应用于成人肿块的筛查。作者报告了1973年1月至1988年12月期间对86例患有具有临床意义的头颈部肿块的儿科患者进行的89次细针穿刺活检。所有细针穿刺诊断均通过后续手术活检、尸检或至少18个月的临床随访得以证实。在确诊的21例肿瘤中，19例为恶性。在进行的89次穿刺中，67例无需后续手术活检。其中11例诊断为转移性或复发性肿瘤并进行了适当治疗。89次穿刺中有15次发现了需要手术干预的先前未确诊的肿瘤。获得了1例假阴性和2例假阳性结果。假阳性诊断未导致根治性治疗，且未因假阴性结果而使患者治疗延迟。敏感性为94.4%，特异性为97.1%。强调了细针穿刺的实用性和成本效益。
