Souquet J C, Berger F, Bonvoisin S, Partensky C, Boulez J, Descos F, Lambert R
Gastroenterology Unit, Hôpital Edouard Herriot, Lyon, France.
Cancer. 1989 Feb 15;63(4):786-90. doi: 10.1002/1097-0142(19890215)63:4<786::aid-cncr2820630430>3.0.co;2-l.
Adenocarcinoma of the stomach occurred in six of 425 consecutive patients with esophageal squamous cell cancer. In two cases, the gastric cancer, which was recognized at 17 and 29 months, respectively, after the nonsurgical treatment of the esophageal tumor, was treated by surgical resection. In three cases, the tumors which were diagnosed simultaneously, were treated by surgery (one case) resection of the gastric tumor and nonsurgical therapy for the esophageal tumor (one case), and nonsurgical therapy for both tumors (one case). In one case, a gastric cancer was resected 6 years before diagnosis of an esophageal tumor and a second cancer in the gastric stump. A nonsurgical protocol was then adopted for both tumors. The association of these two cancers raises questions concerning their epidemiology, diagnosis, prognosis, and management. There is room for nonsurgical multimodality protocols and, in association with surgery, survival was prolonged for more than 1 year in five of six patients.
在425例连续性食管鳞状细胞癌患者中，有6例发生了胃癌。其中2例胃癌分别在食管肿瘤非手术治疗后17个月和29个月被发现，随后接受了手术切除。另外3例同时被诊断出的肿瘤，分别接受了手术（1例）切除胃肿瘤及食管肿瘤非手术治疗（1例），以及两种肿瘤均采用非手术治疗（1例）。还有1例，在食管肿瘤诊断前6年切除了胃癌，之后在胃残端又发现了第二处癌症。随后对两种肿瘤均采用了非手术治疗方案。这两种癌症的并存引发了关于其流行病学、诊断、预后及治疗的诸多问题。非手术多模式治疗方案仍有发展空间，并且在联合手术治疗的情况下，6例患者中有5例生存期延长超过1年。
