Nowak Knut Michael, Witzke Oliver, Sotiropoulos Georgios C, Benkö Tamas, Fiedler Melanie, Timm Jörg, Kribben Andreas, Wilde Benjamin, Saner Fuat, Paul Andreas, Treckmann Jürgen
Department of General, Visceral and Transplantation Surgery, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.
Department of Nephrology, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.
Kidney Int Rep. 2016 Oct 6;2(1):53-59. doi: 10.1016/j.ekir.2016.09.058. eCollection 2017 Jan.
Because of the shortage of available organs for renal transplantation, strategies enabling the safe use of organs from donors with potential chronic infections such as hepatitis C are necessary. The aim of this study was to analyze the outcome of renal transplant donation from hepatitis C virus (HCV)-positive donors.
Between September 2002 and May 2007, 51 kidneys (34 donors) reactive for HCV antibodies were further evaluated. Six kidneys (5 donors) were transplanted to 6 recipients with known chronic HCV infection. The remaining 29 donors underwent extended virological testing. Nine donors were HCV RNA positive and thus not suitable for HCV-negative patients. Twenty donors (21 kidneys) did not have detectable HCV RNA copies and were transplanted into 21 HCV-negative recipients. Clinical outcomes focusing on safety, allograft function, and HCV infection in the recipient were collected.
There were no HCV infections detected in recipients who were HCV negative before transplantation. The extended virological donor screening did not have an impact on median cold ischemia time. Five-year graft survival was 75%.
Organs from anti-HCV-reactive, nonviremic donors can be transplanted safely to HCV-negative recipients.
由于肾移植可用器官短缺，因此有必要采取策略以安全使用来自潜在慢性感染（如丙型肝炎）供体的器官。本研究的目的是分析丙型肝炎病毒（HCV）阳性供体肾移植的结果。
在2002年9月至2007年5月期间，对51份HCV抗体呈反应性的肾脏（34名供体）进行了进一步评估。将6份肾脏（5名供体）移植给6名已知慢性HCV感染的受者。其余29名供体接受了扩展病毒学检测。9名供体HCV RNA呈阳性，因此不适合HCV阴性患者。20名供体（21份肾脏）未检测到HCV RNA拷贝，并将其移植给21名HCV阴性受者。收集了关注安全性、移植肾功能和受者HCV感染情况的临床结果。
移植前HCV阴性的受者未检测到HCV感染。扩展病毒学供体筛查对中位冷缺血时间没有影响。5年移植肾存活率为75%。
来自抗HCV反应性、无病毒血症供体的器官可以安全地移植给HCV阴性受者。
