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一种用于检测X染色体上标记基因座与定量主基因座之间连锁关系的对数优势计分法。

A lod score method for detecting linkage on the X chromosone between a marker locus and a major gene locus for a quantitative.

作者信息

Bock R D, Perline R

出版信息

Behav Genet. 1979 May;9(3):139-49. doi: 10.1007/BF01071297.

DOI:10.1007/BF01071297
PMID:291432
Abstract

A sequential lod-score method is proposed for detecting linkage on the X chromosome between a marker locus and the locus of a major gene influencing a quantitative trait, The method uses information from sons of doubly heterozygous mothers. The average number of families required to detect linkage is substantially less than that of the fixed sample-size method proposed by Hill.

摘要

提出了一种顺序对数计分法，用于检测X染色体上标记基因座与影响数量性状的主基因座之间的连锁关系。该方法利用了双杂合母亲儿子的信息。检测连锁所需的平均家系数量显著少于希尔提出的固定样本量法。

相似文献

1
A lod score method for detecting linkage on the X chromosone between a marker locus and a major gene locus for a quantitative.一种用于检测X染色体上标记基因座与定量主基因座之间连锁关系的对数优势计分法。
Behav Genet. 1979 May;9(3):139-49. doi: 10.1007/BF01071297.
2
An extension of the Maximum Lod Score method to X-linked loci.最大似然比分数法对X连锁基因座的扩展。
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Detection of linkage between a quantitative trait and a marker locus by the lod score method: sample size and sampling considerations.通过对数优势比分法检测数量性状与标记位点之间的连锁：样本量及抽样考量
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Heterozygosity for genes influencing a quantitative trait.
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Models and tests of linkage and association studies of quantitative trait locus for multi-allele marker Loci.多等位基因标记位点数量性状基因座的连锁与关联研究模型及检验
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Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12.有序子集连锁分析支持16号染色体p12区域存在年龄相关性黄斑变性的易感基因座。
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本文引用的文献

1
Sequential tests for the detection of linkage.用于检测连锁的序贯检验。
Am J Hum Genet. 1955 Sep;7(3):277-318.
2
[Distribution of frequecies, interpretation of genetic determinism of quantitative characteristics and research of "major genes"].[频率分布、数量性状的遗传决定论解释及“主基因”研究]
Biometrics. 1968 Jun;24(2):277-93.
3
On the detection and estimation of linkage between a locus influencing a quantitative character and a marker locus.关于影响数量性状的基因座与标记基因座之间连锁关系的检测与估计
Biometrics. 1970 Sep;26(3):451-64.
4
A general model for the genetic analysis of pedigree data.家系数据遗传分析的通用模型。
Hum Hered. 1971;21(6):523-42. doi: 10.1159/000152448.
5
Linkage between marker loci and those affecting a quantitative trait.标记基因座与影响数量性状的基因座之间的连锁。
Behav Genet. 1973 Dec;3(4):389-91. doi: 10.1007/BF01070222.
6
The analysis of quantitative traits for simple genetic models from parental, F 1 and backcross data.基于亲本、F1和回交数据对简单遗传模型的数量性状分析。
Genetics. 1973 Apr;73(4):695-711. doi: 10.1093/genetics/73.4.695.
7
Further evidence of sex-linked major-gene influence on human spatial visualizing ability.性连锁主基因对人类空间视觉能力影响的进一步证据。
Am J Hum Genet. 1973 Jan;25(1):1-14.
8
Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.人类家系中重组率的估计：人类连锁研究似然性的高效计算。
Am J Hum Genet. 1974 Sep;26(5):588-97.
9
Heritability estimates and genetic and environmental correlations for the human immunoglobulins G, M, and A.人类免疫球蛋白G、M和A的遗传力估计以及遗传和环境相关性
Am J Hum Genet. 1974 Jan;26(1):1-12.
10
The investigation of linkage between a quantitative trait and a marker locus.数量性状与标记位点之间的连锁研究。
Behav Genet. 1972 Mar;2(1):3-19. doi: 10.1007/BF01066731.