通过对数优势比分法检测数量性状与标记位点之间的连锁：样本量及抽样考量
Detection of linkage between a quantitative trait and a marker locus by the lod score method: sample size and sampling considerations.
作者信息
Demenais F, Lathrop G M, Lalouel J M
机构信息
Unité de Recherches de Génétique Epidémiologique, I.N.S.E.R.M. U.155, Château de Longchamp, Bois de Boulogne, Paris, France.
出版信息
Ann Hum Genet. 1988 Jul;52(3):237-46. doi: 10.1111/j.1469-1809.1988.tb01101.x.
A simulation study is here conducted to measure the power of the lod score method to detect linkage between a quantitative trait and a marker locus in various situations. The number of families necessary to detect such linkage with 80% power is assessed for different sets of parameters at the trait locus and different values of the recombination fraction. The effects of varying the mode of sampling families and the sibship size are also evaluated.
本文进行了一项模拟研究，以衡量对数优势计分法在各种情况下检测数量性状与标记位点之间连锁关系的效能。针对性状位点不同的参数集以及不同的重组率值，评估了以80%的效能检测这种连锁关系所需的家系数量。还评估了改变家系抽样方式和同胞组大小的影响。
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