Institute of Experimental Botany of the Czech Academy of Sciences, Rozvojová 263, 16502 Prague, Czech Republic.
Int J Mol Sci. 2017 Nov 16;18(11):2429. doi: 10.3390/ijms18112429.
The interactions between mitochondria and nucleus substantially influence plant development, stress response and morphological features. The prominent example of a mitochondrial-nuclear interaction is cytoplasmic male sterility (CMS), when plants produce aborted anthers or inviable pollen. The genes responsible for CMS are located in mitochondrial genome, but their expression is controlled by nuclear genes, called fertility restorers. Recent explosion of high-throughput sequencing methods enabled to study transcriptomic alterations in the level of non-coding RNAs under CMS biogenesis. We summarize current knowledge of the role of nucleus encoded regulatory non-coding RNAs (long non-coding RNA, microRNA as well as small interfering RNA) in CMS. We also focus on the emerging data of non-coding RNAs encoded by mitochondrial genome and their possible involvement in mitochondrial-nuclear interactions and CMS development.
线粒体和细胞核之间的相互作用极大地影响植物的发育、应激反应和形态特征。线粒体-核相互作用的突出例子是细胞质雄性不育（CMS），此时植物产生败育的花药或不能存活的花粉。导致 CMS 的基因位于线粒体基因组中，但它们的表达受核基因控制，称为育性恢复基因。最近高通量测序方法的爆炸式发展使得能够研究 CMS 发生过程中非编码 RNA 水平的转录组变化。我们总结了核编码调控非编码 RNA（长非编码 RNA、microRNA 以及小干扰 RNA）在 CMS 中的作用的现有知识。我们还重点介绍了线粒体基因组编码的非编码 RNA 的新数据及其在线粒体-核相互作用和 CMS 发育中的可能参与。
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