School of Chemistry and ‡Department of Chemical and Environmental Engineering, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom.
Org Lett. 2017 Dec 1;19(23):6396-6399. doi: 10.1021/acs.orglett.7b03252. Epub 2017 Nov 16.
The iron(III)-catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Significantly, this multicomponent reaction is compatible with electrophilic alkynes; control experiments demonstrate the importance of the catalyst in promoting pyridinium ylide formation over background reactivity.
报道了一种铁(III)催化的从商业可得的炔烃、吡啶和重氮前体制备吲哚嗪的方法。该温和、简便的方法对各种溶剂具有耐受性，并且只需 0.25 mol%的[Fe(TPP)Cl]即可进行。显著的是，该多组分反应与亲电炔烃兼容；对照实验证明了催化剂在促进吡啶翁形成方面相对于背景反应的重要性。
