Department of Chemistry, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
Org Lett. 2017 Dec 1;19(23):6380-6383. doi: 10.1021/acs.orglett.7b03239. Epub 2017 Nov 16.
Triazoliptycene fluorophores have been designed and synthesized, in which a three-dimensional propeller-like iptycene motif is employed to suppress intermolecular π-π stacking in the solid state. Key to the success of this modular synthesis is a stereoelectronic bias imposed by the iptycene scaffold, which assists the desired regioselectivity in the C-N cross-coupling step as the last-stage structure diversification from a common precursor.
三唑并芴类荧光团已被设计和合成，其中采用了三维螺旋桨状芴基作为 motif 来抑制固态下的分子间π-π堆积。这种模块化合成的关键在于芴基骨架所施加的立体电子偏向性，它有助于在 C-N 交叉偶联步骤中实现所需的区域选择性，作为最后阶段从共同前体进行结构多样化的结构。
