从酮、胺和一氧化碳到 4-喹诺酮：钯催化的氧化羰基化反应。

From Ketones, Amines, and Carbon Monoxide to 4-Quinolones: Palladium-Catalyzed Oxidative Carbonylation.

机构信息

The Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.

State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, P. R. China.

出版信息

Org Lett. 2017 Dec 1;19(23):6432-6435. doi: 10.1021/acs.orglett.7b03337. Epub 2017 Nov 16.

DOI:10.1021/acs.orglett.7b03337

PMID:29144766

Abstract

A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from inexpensive chemicals.

摘要

开发了一种新型的钯催化酮、胺和一氧化碳的氧化羰基化方法，用于合成 4-喹诺酮。该方案为从廉价化学品构建有用的 4-喹诺酮衍生物提供了一条直接途径。