Lau C P, Ward D E, Camm A J
Department of Cardiological Sciences, St. George's Hospital Medical School, London, England.
Chest. 1989 Feb;95(2):352-8. doi: 10.1378/chest.95.2.352.
Ventilatory changes correlate with the heart rate response during exercise, and such changes have been used to determine an appropriate chronotropic response in the Biorate (RDP3 and MB-1) and Meta pacemakers, both of which use a thoracic impedance measurement principle. Ten patients with the Biorate and 11 patients with the Meta were studied. In both groups, significant rate response and improvement in exercise duration compared with fixed rate ventricular pacing were achieved during symptom-limited treadmill exercise tests, with good correlations between the pacing rate and estimated oxygen consumption. Motion artefacts affected the measured impedance of both pacemakers, with rate response occurring during arm movements in the absence of respiratory activity. This observation suggested that both pacemakers have the potential of activity sensing. The earlier version of the Biorate (RDP3) was limited by myopotential interference, and erosion of the auxiliary lead can be problematic in some patients.
通气变化与运动期间的心率反应相关，并且这种变化已被用于在Biorate（RDP3和MB - 1）和Meta起搏器中确定适当的变时性反应，这两种起搏器均采用胸段阻抗测量原理。对10例使用Biorate的患者和11例使用Meta的患者进行了研究。在两组中，在症状限制的平板运动试验期间，与固定频率心室起搏相比，实现了显著的心率反应和运动持续时间的改善，起搏频率与估计的耗氧量之间具有良好的相关性。运动伪影影响了两种起搏器的测量阻抗，在没有呼吸活动的情况下，手臂运动期间会出现心率反应。这一观察结果表明，两种起搏器都具有活动感知的潜力。Biorate的早期版本（RDP3）受到肌电位干扰的限制，并且在一些患者中，辅助导线的侵蚀可能会成为问题。
