Béreau M, Tatu L
Front Neurol Neurosci. 2018;41:98-103. doi: 10.1159/000475701. Epub 2017 Nov 16.
Different eponyms such as "Wood syndrome," Meige syndrome, "Brueghel syndrome," "Blepharospasm plus syndrome" have been used to describe segmental craniocervical dystonias. These facial and/or oromandibular movement disorders are characterized by muscle contractions and spasms involving eyes, facial region, and sometimes pharynx, jaw, floor of the mouth, and tongue. The pathophysiology of craniocervical dystonia is poorly understood, but abnormal plasticity and impaired inhibition are suspected. Injection of botulinum toxin appears to be the best therapeutic option for treating segmental craniocervical dystonia. The objective of this chapter is to depict the history of segmental craniocervical dystonia in order to delineate the phenotypic spectrum of the disorders and to distinguish this entity from other facial and/or oromandibular movement disorders.
不同的命名，如“伍德综合征”、梅杰综合征、“勃鲁盖尔综合征”、“眼睑痉挛加综合征”，已被用于描述节段性颅颈肌张力障碍。这些面部和/或口下颌运动障碍的特征是涉及眼睛、面部区域，有时还包括咽部、下颌、口腔底部和舌头的肌肉收缩和痉挛。颅颈肌张力障碍的病理生理学尚不清楚，但怀疑存在异常可塑性和抑制受损。注射肉毒杆菌毒素似乎是治疗节段性颅颈肌张力障碍的最佳治疗选择。本章的目的是描述节段性颅颈肌张力障碍的历史，以勾勒出这些疾病的表型谱，并将这一实体与其他面部和/或口下颌运动障碍区分开来。
