Gilbert G J
Department of Physiology and Biophysics, University of South Florida, Tampa, USA.
Neurology. 1996 Jun;46(6):1767-9. doi: 10.1212/wnl.46.6.1767.
A critical historical evaluation of the cranial dystonias supports the separation of the dystonia of the motor trigeminal nerve producing a widely opened mouth (Brueghel syndrome) from the more common facial dystonias with blepharospasm (Meige syndrome). In a patient with Brueghel syndrome, paroxysmal hyperpnea coincided with dystonic gaping; the finding of upbeating nystagmus suggests pontine localization in the pathogenesis of this rare disorder.
对颅肌张力障碍的批判性历史评估支持将导致嘴巴广泛张开的运动性三叉神经肌张力障碍（勃鲁盖尔综合征）与更常见的伴有眼睑痉挛的面部肌张力障碍（梅杰综合征）区分开来。在一名患有勃鲁盖尔综合征的患者中，阵发性呼吸急促与肌张力障碍性张口同时出现；向上跳动性眼球震颤的发现提示这种罕见疾病的发病机制定位于脑桥。
