姜黄素通过调节rd1小鼠视网膜中小胶质细胞的激活来延缓视网膜变性。
Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice.
作者信息
Wang Yanhe, Yin Zhiyuan, Gao Lixiong, Sun Dayu, Hu Xisu, Xue Langyue, Dai Jiaman, Zeng YuXiao, Chen Siyu, Pan Boju, Chen Min, Xie Jing, Xu Haiwei
机构信息
Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China.
Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China.
出版信息
Cell Physiol Biochem. 2017;44(2):479-493. doi: 10.1159/000485085. Epub 2017 Nov 17.
BACKGROUND/AIMS: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this disease.
METHODS
Immunofluorescence staining, electroretinogram recordings, and behavioral tests were used to analyze the effects of curcumin and the underlying mechanism in retinal degeneration 1 (rd1) mice.
RESULTS
The number of apoptotic cells in the retina of rd1 mice at postnatal day 14 significantly decreased with curcumin treatment and visual function was improved. The activation of microglia and secretion of chemokines and matrix metalloproteinases in the retina were inhibited by curcumin. These effects were also observed in a co-culture of BV2 microglial cells and retina-derived 661W cells.
CONCLUSIONS
Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice. Thus, it may be an effective treatment for neurodegenerative disorders such as RP.
背景/目的：视网膜色素变性（RP）的特征是光感受器退化，目前尚无针对该疾病的有效治疗方法。然而，姜黄素在RP大鼠和猪模型中已显示出神经保护作用，因此，可能对该疾病具有神经保护作用。
方法
采用免疫荧光染色、视网膜电图记录和行为测试来分析姜黄素在视网膜变性1（rd1）小鼠中的作用及其潜在机制。
结果
在出生后第14天，姜黄素治疗可使rd1小鼠视网膜中的凋亡细胞数量显著减少，并改善视觉功能。姜黄素可抑制视网膜中小胶质细胞的激活以及趋化因子和基质金属蛋白酶的分泌。在BV2小胶质细胞与视网膜来源的661W细胞的共培养中也观察到了这些作用。
结论
姜黄素通过抑制rd1小鼠视网膜中的小胶质细胞激活来延缓视网膜变性。因此，它可能是治疗RP等神经退行性疾病的有效方法。
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