Paschal D C, DiPietro E S, Phillips D L, Gunter E W
Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Atlanta, Georgia 30333.
Environ Res. 1989 Feb;48(1):17-28. doi: 10.1016/s0013-9351(89)80081-7.
Concentrations of 28 metals were determined in hair samples from 199 children (age less than or equal to 12 years) and 322 adults (age 13-73) years. Levels of calcium, barium, magnesium zinc, and strontium all show a similar age-dependent increase up to about 12-14 years; levels of aluminum show a decrease with age. Relationships of elemental concentrations with age were examined by using correlation, linear regression, t tests, and discriminant analysis. Statistically significant differences in mean concentration values between children and adults were shown for these metals. Discriminant analysis gave about 95% accuracy in classifying a test data set into the categories of children and adults. A hypothesis suggested by the data is that there is an age-dependent excretion in hair of alkali metals during skeletal growth and development. The observed decrease in aluminum is largely unexplained at this time.
测定了199名儿童（年龄小于或等于12岁）和322名成年人（年龄13 - 73岁）头发样本中28种金属的浓度。钙、钡、镁、锌和锶的含量在12 - 14岁左右均呈现出类似的随年龄增长的增加趋势；铝的含量则随年龄下降。通过相关性分析、线性回归、t检验和判别分析研究了元素浓度与年龄的关系。这些金属在儿童和成年人之间的平均浓度值存在统计学上的显著差异。判别分析在将测试数据集分类为儿童和成年人类别时的准确率约为95%。数据提出的一个假设是，在骨骼生长发育过程中，碱金属在头发中的排泄存在年龄依赖性。目前，铝含量的下降在很大程度上无法解释。
