Kishimoto T, Okada K, Sato T, Ono T, Ito H
Department of Clinical Investigation, Kure Kyosai Hospital, Japan.
Environ Res. 1989 Feb;48(1):42-8. doi: 10.1016/s0013-9351(89)80083-0.
There has been a recent increase in the number of patients with malignant mesothelioma in parts of Japan where Naval shipyards were located during World War II. This can be attributed to asbestos exposure during work in the shipyard. We have studied eight patients who were seen between 1984 and 1986 in Kure Kyosai Hospital. All had a history of asbestos exposure, seven in a Naval shipyard. In these seven cases, the latent period between exposure and the appearance of mesothelioma was 43-49 years. Quantification of asbestos bodies in the lung indicated a high concentration in all patients, giving further weight to the concept that asbestos is an etiologic factor in the genesis of mesothelioma. The major types of asbestos fibers were crocidolite and amosite. The study of structural features of these two types may provide a clue to the pathogenesis of the disease.
在第二次世界大战期间设有海军造船厂的日本部分地区，恶性间皮瘤患者的数量最近有所增加。这可归因于在造船厂工作期间接触石棉。我们研究了1984年至1986年间在吴市急救医院就诊的8例患者。所有患者都有石棉接触史，其中7例在海军造船厂工作。在这7例病例中，接触石棉至间皮瘤出现的潜伏期为43至49年。肺中石棉小体的定量分析表明，所有患者体内的石棉小体浓度都很高，这进一步证明了石棉是间皮瘤发病的一个病因。石棉纤维的主要类型为青石棉和铁石棉。对这两种类型石棉纤维结构特征的研究可能为该疾病的发病机制提供线索。
