Kulprachakarn Kanokwan, Ounjaijean Sakaewan, Wungrath Jukkrit, Mani Raj, Rerkasem Kittipan
1 NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
2 Nutrition Research Unit, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
Int J Low Extrem Wounds. 2017 Dec;16(4):244-250. doi: 10.1177/1534734617737659. Epub 2017 Nov 16.
The diabetic foot ulcer (DFU) is an invariably common complication of diabetes mellitus, it is also a significant cause of amputation as well as extended hospitalization. As most patients with DFU suffer from malnutrition, which has been related to improper metabolic micronutrients status, alterations can affect impaired wound healing process. Micronutrients and herbal remedies applications present a wide range of health advantages to patients with DFU. The purpose of this review is to provide current evidence on the potential effect of dietary supplementations such as vitamins A, C, D, E, magnesium, zinc, copper, iron, boron, and such naturally occurring compounds as Aloe vera, Naringin, and Radix Astragali (RA) and Radix Rehmanniae (RR) in the administration of lower extremity wounds, especially in DFU, and to present some insights for applications in the treatment of DFU patients in the future.
糖尿病足溃疡（DFU）是糖尿病常见的并发症，也是截肢和延长住院时间的重要原因。由于大多数DFU患者存在营养不良，这与代谢性微量营养素状态异常有关，这些改变会影响受损的伤口愈合过程。微量营养素和草药疗法的应用为DFU患者带来了广泛的健康益处。本综述的目的是提供当前证据，证明维生素A、C、D、E、镁、锌、铜、铁、硼等膳食补充剂以及芦荟、柚皮苷、黄芪（RA）和生地黄（RR）等天然化合物在下肢伤口治疗，尤其是DFU治疗中的潜在作用，并为未来DFU患者的治疗应用提供一些见解。
