Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
J Am Acad Dermatol. 2018 Jan;78(1):29-39.e7. doi: 10.1016/j.jaad.2017.09.012. Epub 2017 Nov 14.
Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging.
We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age.
Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women. 23andMe genotyping determined genetic ancestry.
Gene expression and ontologic analysis revealed progressive changes from the 20s to the 70s in pathways related to oxidative stress, energy metabolism, senescence, and epidermal barrier; these changes were accelerated in the 60s and 70s. The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger.
Broader application of these findings (eg, across races and Fitzpatrick skin types) will require further studies.
This study demonstrates a wide range of molecular processes in skin affected by aging, providing relevant targets for improving the condition of aging skin at different life stages and defining a molecular pattern of epidermal gene expression in women who appear younger than their chronologic age.
包括紫外线照射在内的内在和外在因素会导致皮肤出现可见的老化迹象。
我们评估了 20 至 74 岁的白人女性的曝光和防晒皮肤中发生的分子变化，其中一些人的实际年龄看起来比其生理年龄年轻很多。
对 158 名女性的暴露（面部和背部前臂）或防晒（臀部）身体部位的皮肤活检样本进行组织学和转录组学分析。23andMe 基因分型确定遗传背景。
基因表达和本体论分析显示，与氧化应激、能量代谢、衰老和表皮屏障相关的途径在 20 多岁到 70 多岁之间逐渐发生变化；这些变化在 60 多岁和 70 多岁时加速。在那些看起来更年轻的女性亚组中，基因表达模式与实际更年轻的女性相似。
更广泛地应用这些发现（例如，跨越种族和 Fitzpatrick 皮肤类型）将需要进一步的研究。
这项研究展示了受衰老影响的皮肤中广泛的分子过程，为改善不同生命阶段衰老皮肤的状况提供了相关靶点，并定义了实际年龄比生理年龄年轻的女性的表皮基因表达的分子模式。
