Miyamoto Kukizo, Inoue Yasuko, Yan Xianghong, Yagi Shiomi, Suda Sudarsana, Furue Masutaka
Research and Development, Kobe Innovation Center, Procter and Gamble Innovation GK, Kobe 651-0088, Japan.
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
J Clin Med. 2023 Feb 1;12(3):1168. doi: 10.3390/jcm12031168.
Facial skin aging is an important psychophysical and social concern, especially in women. We compared facial parameters reflecting aging of the skin in 1999 and 2010 in 86 female volunteers. Then, all subjects applied three ferment filtrate-containing skin care products (G3 products; SK-II Facial Treatment Essence, SK-II Cellumination Essence, and SK-II Skin Signature Cream) twice daily for 12 months (M), with the skin parameters being measured at 2 M, 8 M, and 12 M during this period. Facial skin aging parameters such as wrinkles, hyperpigmented spots, and roughness significantly deteriorated during the 11-year interval. This 11-year aging process was associated with reduced hydration and increased transepidermal water loss (TEWL). Notably, treatment with G3 products significantly and cumulatively increased skin hydration with a correlated reduction of TEWL during the 12 M treatment period. Such treatment also significantly and cumulatively reversed the 11-year facial skin aging in the three parameters of wrinkles, spots, and roughness. These results suggest that facial skin retains the potential to recover from the aging process when it is applied with appropriate cosmetic agents.
面部皮肤老化是一个重要的心理生理和社会问题，尤其在女性中。我们比较了86名女性志愿者在1999年和2010年反映皮肤老化的面部参数。然后，所有受试者每天两次使用三种含发酵滤液的护肤品（G3产品；SK-II护肤精华露、SK-II晶致美肤精华露和SK-II肌源修护精华霜），持续12个月（M），在此期间于第2个月（M）、第8个月（M）和第12个月（M）测量皮肤参数。在这11年的间隔期内，皱纹、色素沉着斑和粗糙度等面部皮肤老化参数显著恶化。这一11年的老化过程与皮肤水分减少和经表皮水分流失（TEWL）增加有关。值得注意的是，在12个月的治疗期内，使用G3产品进行治疗可显著且累积地增加皮肤水分，并相应减少TEWL。这种治疗还显著且累积地逆转了皱纹、斑点和粗糙度这三个参数方面11年的面部皮肤老化。这些结果表明，当使用适当的美容剂时，面部皮肤具有从老化过程中恢复的潜力。
