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1
Inflammatory molecule reduction with hydroxyurea therapy in children with sickle cell anemia.羟基脲疗法对镰状细胞贫血患儿炎症分子的减少作用。
Haematologica. 2018 Feb;103(2):e50-e54. doi: 10.3324/haematol.2017.177360. Epub 2017 Nov 16.
2
Effects of hydroxyurea on the membrane of erythrocytes and platelets in sickle cell anemia.羟基脲对镰状细胞贫血患者红细胞和血小板膜的影响。
Haematologica. 2004 Mar;89(3):273-80.
3
Hydroxyurea for the treatment of sickle cell anemia.羟基脲用于治疗镰状细胞贫血。
N Engl J Med. 2008 Mar 27;358(13):1362-9. doi: 10.1056/NEJMct0708272.
4
Sickle cell patients find a brand New World.镰状细胞病患者迎来了全新的世界。
N J Med. 1999 Aug;96(8):23-5.
5
Hydroxyurea for sickle-cell anaemia in Africa: mind the gap.非洲镰状细胞贫血的羟基脲治疗：注意差距。
Lancet Glob Health. 2015 Mar;3(3):e124-5. doi: 10.1016/S2214-109X(14)70371-7.
6
Hydroxyurea increases fetal hemoglobin production in sickle cell anemia.羟基脲可增加镰状细胞贫血患者的胎儿血红蛋白生成。
Trans Assoc Am Physicians. 1984;97:268-74.
7
[From Hemoglobin SS to SF: interest of hydroxyurea in the management of sickle cell disease in two Congolese children and review of the literature].[从血红蛋白SS到SF：羟基脲在两名刚果儿童镰状细胞病管理中的作用及文献综述]
Pan Afr Med J. 2015 Jun 15;21:124. doi: 10.11604/pamj.2015.21.124.5784. eCollection 2015.
8
An age dependent response to hydroxyurea in pediatric sickle cell anemia patients with alpha thalassemia trait.α地中海贫血特征的小儿镰状细胞贫血患者对羟基脲的年龄依赖性反应。
Blood Cells Mol Dis. 2017 Jul;66:19-23. doi: 10.1016/j.bcmd.2017.07.004. Epub 2017 Jul 31.
9
Hydroxyurea in very young children with sickle cell anemia is not a cure-all.羟基脲对镰状细胞贫血的幼儿并非万灵药。
J Pediatr. 2001 Dec;139(6):763-4. doi: 10.1067/mpd.2001.120093.
10
A clinically meaningful fetal hemoglobin threshold for children with sickle cell anemia during hydroxyurea therapy.羟基脲治疗期间镰状细胞贫血患儿具有临床意义的胎儿血红蛋白阈值。
Am J Hematol. 2017 Dec;92(12):1333-1339. doi: 10.1002/ajh.24906. Epub 2017 Sep 28.

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1
Angiopoietin-2 is associated with sickle cell complications, including stroke risk, and decreases with hydroxyurea therapy.血管生成素-2与镰状细胞并发症相关，包括中风风险，并且在羟基脲治疗后会降低。
Blood Vessel Thromb Hemost. 2024 Feb 8;1(1):100001. doi: 10.1016/j.bvth.2024.100001. eCollection 2024 Mar.
2
Leucine-Rich Alpha-2 Glycoprotein 1 (LRG1) and Proangiogenic Mediators in Sickle Cell Disease.富含亮氨酸的α-2糖蛋白1（LRG1）与镰状细胞病中的促血管生成介质
Turk J Haematol. 2025 Aug 29;42(3):253-255. doi: 10.4274/tjh.galenos.2025.2025.0262. Epub 2025 Jul 22.
3
Adding hydroxyurea to chronic transfusion therapy for sickle cell anemia reduces transfusion burden.在镰状细胞贫血的慢性输血治疗中添加羟基脲可减轻输血负担。
Transfusion. 2025 Jan;65(1):38-49. doi: 10.1111/trf.18073. Epub 2024 Nov 24.
4
Gene-environmental influence of space and microgravity on red blood cells with sickle cell disease.太空和微重力对镰状细胞病红细胞的基因-环境影响。
NPJ Genom Med. 2024 Sep 30;9(1):44. doi: 10.1038/s41525-024-00427-7.
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Immune Cell Profiles of Patients with Sickle Cell Disease during Parvovirus B19-Induced Transient Red Cell Aplasia.细小病毒B19诱导的短暂红细胞再生障碍期间镰状细胞病患者的免疫细胞谱
Vaccines (Basel). 2024 Aug 29;12(9):984. doi: 10.3390/vaccines12090984.
6
Proinflammatory state promotes red blood cell alloimmunization in pediatric patients with sickle cell disease.炎症状态促进小儿镰状细胞病患者的红细胞同种免疫。
Blood Adv. 2023 Sep 12;7(17):4799-4808. doi: 10.1182/bloodadvances.2022008647.
7
Challenges in the treatment of melanoma with BRAF and MEK inhibitors in patients with sickle cell disease: case report and review of the literature.镰状细胞病患者使用BRAF和MEK抑制剂治疗黑色素瘤的挑战：病例报告及文献综述
Ther Adv Hematol. 2023 Mar 15;14:20406207231155991. doi: 10.1177/20406207231155991. eCollection 2023.
8
Hypothesis: Low Vitamin A and D Levels Worsen Clinical Outcomes When Children with Sickle Cell Disease Encounter Parvovirus B19.假说：当镰状细胞病患儿遭遇细小病毒 B19 时，低维生素 A 和 D 水平会使临床结果恶化。
Nutrients. 2022 Aug 19;14(16):3415. doi: 10.3390/nu14163415.
9
Vaso-occlusive crisis in sickle cell disease: a vicious cycle of secondary events.镰状细胞病中的血管闭塞性危象：继发性事件的恶性循环。
J Transl Med. 2021 Sep 20;19(1):397. doi: 10.1186/s12967-021-03074-z.
10
Longitudinal effect of disease-modifying therapy on tricuspid regurgitant velocity in children with sickle cell anemia.疾病修正治疗对镰状细胞贫血患儿三尖瓣反流速度的纵向影响。
Blood Adv. 2021 Jan 12;5(1):89-98. doi: 10.1182/bloodadvances.2020003197.

本文引用的文献

1
Simvastatin reduces vaso-occlusive pain in sickle cell anaemia: a pilot efficacy trial.辛伐他汀可减轻镰状细胞贫血的血管闭塞性疼痛：一项初步疗效试验。
Br J Haematol. 2017 May;177(4):620-629. doi: 10.1111/bjh.14580. Epub 2017 Mar 28.
2
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease.克立硃单抗用于预防镰状细胞病的疼痛危象
N Engl J Med. 2017 Feb 2;376(5):429-439. doi: 10.1056/NEJMoa1611770. Epub 2016 Dec 3.
3
Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea.镰状细胞病患者循环环境刺激关键内皮细胞血管生成机制，而羟基脲则使其减弱。
Haematologica. 2015 Jun;100(6):730-9. doi: 10.3324/haematol.2014.119727. Epub 2015 Mar 13.
4
Serum IL-6, IL-10, and TNFα levels in pediatric sickle cell disease patients during vasoocclusive crisis and steady state condition.小儿镰状细胞病患者在血管闭塞性危象和稳定状态期间的血清白细胞介素-6、白细胞介素-10和肿瘤坏死因子α水平。
Cytokine. 2015 Mar;72(1):43-7. doi: 10.1016/j.cyto.2014.11.030. Epub 2015 Jan 5.
5
Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition.镰状细胞病患者血管阻塞危象和稳定状态时促炎细胞因子水平的改变。
Eur Cytokine Netw. 2013 Mar;24(1):45-52. doi: 10.1684/ecn.2013.0328.
6
Cytokine levels in the serum of healthy subjects.健康受试者血清中的细胞因子水平。
Mediators Inflamm. 2013;2013:434010. doi: 10.1155/2013/434010. Epub 2013 Mar 7.
7
Analysis of serum and plasma identifies differences in molecular coverage, measurement variability, and candidate biomarker selection.分析血清和血浆可识别分子覆盖度、测量变异性和候选生物标志物选择方面的差异。
Proteomics Clin Appl. 2012 Jun;6(5-6):297-303. doi: 10.1002/prca.201100061.
8
Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin.羟基脲疗法治疗镰状细胞贫血小鼠模型通过下调 E-选择素来抑制肺炎球菌病的进展。
Blood. 2012 Feb 23;119(8):1915-21. doi: 10.1182/blood-2011-08-374447. Epub 2011 Nov 30.
9
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.GMI-1070，一种新型的泛选择素拮抗剂，可逆转镰状细胞小鼠的急性血管闭塞。
Blood. 2010 Sep 9;116(10):1779-86. doi: 10.1182/blood-2009-12-260513. Epub 2010 May 27.
10
Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy.镰状细胞贫血患者血浆和白细胞中细胞因子及炎症介质水平的改变以及羟基脲治疗的效果
J Leukoc Biol. 2009 Feb;85(2):235-42. doi: 10.1189/jlb.0708445. Epub 2008 Nov 12.

Inflammatory molecule reduction with hydroxyurea therapy in children with sickle cell anemia.

作者信息

Penkert Rhiannon R, Hurwitz Julia L, Thomas Paul, Rosch Jason, Dowdy Jola, Sun Yilun, Tang Li, Hankins Jane S

机构信息

Department of Infectious Diseases, St. Jude Children's Research Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.

出版信息

Haematologica. 2018 Feb;103(2):e50-e54. doi: 10.3324/haematol.2017.177360. Epub 2017 Nov 16.

DOI:10.3324/haematol.2017.177360
PMID:29146708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5792285/
Abstract
摘要