Hauptman Nina, Glavač Damjan
Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Gastroenterol Res Pract. 2017;2017:2195361. doi: 10.1155/2017/2195361. Epub 2017 Sep 25.
Mortality and morbidity associated with colorectal cancer (CRC) are increasing globally, partly due to lack of early detection of the disease. The screening is usually performed with colonoscopy, which is invasive and unpleasant, discouraging participation in the screening. As a source of noninvasive and easily accessible biomarkers, liquid biopsies are emerging. Blood-based biomarkers have the potential as diagnostic and prognostic tool in CRC. Early stage detection of CRC with high sensitivity and specificity would likely lead to higher participation in the screening test. It would also improve the prognosis of the disease and improve the recurrence risk. In this review, we summarize the potential biomarkers for early detection and monitoring of CRC.
全球范围内，与结直肠癌（CRC）相关的死亡率和发病率正在上升，部分原因是该疾病缺乏早期检测。筛查通常通过结肠镜检查进行，这种检查具有侵入性且令人不适，从而阻碍了人们参与筛查。作为非侵入性且易于获取的生物标志物来源，液体活检正在兴起。基于血液的生物标志物有潜力成为结直肠癌的诊断和预后工具。以高灵敏度和特异性早期检测结直肠癌可能会提高筛查测试的参与度。这也将改善疾病的预后并降低复发风险。在本综述中，我们总结了用于结直肠癌早期检测和监测的潜在生物标志物。
