ABO血型与不稳定型心绞痛患者冠状动脉疾病严重程度之间的关联
Association between ABO blood group and severity of coronary artery disease in unstable angina.
作者信息
Omidi Negar, Rafie Khorgami Mohammad, Effatpanah Mohammad, Khatami Farnaz, Mashhadizadeh Mehrpouya, Jalali Arash, Hekmat Hamidreza
机构信息
Assistant Professor, Cardiac Primary Prevention Research Center, Tehran Heart Center AND Department of Cardiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Assistant Professor, Rajaie Heart Center AND Department of Pediatric Cardiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
出版信息
ARYA Atheroscler. 2017 Jul;13(4):172-175.
BACKGROUND
ABO blood groups are genetically transmitted through chromosome 9 at locus 9q34. It is supposed that there is a locus on 9p21, which has a role in developing coronary artery disease.
METHODS
Our study population consisted of 309 patients with unstable angina admitted to the Ziaeian Hospital, Tehran, Iran, who underwent coronary angiography. The association between types of blood group (O and non-O) with the severity of coronary artery disease was investigated.
RESULTS
Compared to the non-O groups, the O group had more severe coronary artery involvement (P = 0.004).
CONCLUSION
Our study supports recent suggestions on the association between blood group and coronary artery disease. Further studies are needed to evaluate the effect of blood group on atherosclerosis.
背景
ABO血型通过9号染色体上9q34位点进行基因传递。据推测，9p21上存在一个位点，其在冠状动脉疾病的发生发展中起作用。
方法
我们的研究对象包括309例入住伊朗德黑兰齐亚埃安医院的不稳定型心绞痛患者，这些患者均接受了冠状动脉造影。研究了血型（O型和非O型）与冠状动脉疾病严重程度之间的关联。
结果
与非O型组相比，O型组冠状动脉受累更严重（P = 0.004）。
结论
我们的研究支持了近期关于血型与冠状动脉疾病之间关联的观点。需要进一步研究来评估血型对动脉粥样硬化的影响。
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