Ashraf M, Biswas J, Dam A, Bhowmick A, Sing V, Nayak S
Department of Surgical Oncology, Chittaranjan National Cancer Institute (CNCI), 37, S P Mukherjee Road, Kolkata-26, India.
Department of Head and Neck Surgery, Chittaranjan National Cancer Institute (CNCI), 37, S P Mukherjee Road, Kolkata-26, India.
World J Oncol. 2010 Feb;1(1):28-34. doi: 10.4021/wjon2010.02.191w. Epub 2010 Feb 1.
Five-year survival in squamous cell carcinoma of maxillary antrum is low. This article examines the results of various approaches to treatment as given in our hospital in past 26 years.
From 1979 to 2005, 379 patients with squamous cell carcinoma of maxillary antrum managed with curative intent were studied. Twenty-eight patients had T2, 237 patients had T3, and 114 had T4 tumors. The N classification was N0 in 316 patients, N1 in 21 patients, N2a in 28 patients and N2b in 14 patients. Treatment to the primary site comprised of surgery (Sx) and radiation therapy (RT) in 284 patients, RT alone in 57 patients and chemotherapy (CTx) with radiotherapy in 38 patients.
There was a difference in survival between patients who underwent Sx with RT compared with patients who received RT alone or CTx with RT. The most common pattern of recurrence was in the primary site, 187 (49.3%) patients. Local control at 3 and 5 years was 71% and 63.8% respectively in Sx with RT, 31.6% and 28% respectively in RT, and 28.9% and 26% in CTx with RT group.
The type of treatment to the primary site is an important determinant of survival and local control. Surgery with radiation is a better treatment option.
上颌窦鳞状细胞癌的五年生存率较低。本文探讨了我院过去26年中采用的各种治疗方法的结果。
对1979年至2005年期间379例接受根治性治疗的上颌窦鳞状细胞癌患者进行研究。28例患者为T2期，237例患者为T3期，114例患者为T4期肿瘤。N分期为：316例患者为N0，21例患者为N1，28例患者为N2a，14例患者为N2b。原发部位的治疗包括284例患者接受手术（Sx）和放疗（RT），57例患者单纯接受放疗，38例患者接受化疗（CTx）联合放疗。
接受手术联合放疗的患者与单纯接受放疗或化疗联合放疗的患者在生存率上存在差异。最常见的复发部位是原发部位，有187例（49.3%）患者。手术联合放疗组3年和5年的局部控制率分别为71%和63.8%，单纯放疗组分别为31.6%和28%，化疗联合放疗组分别为28.9%和26%。
原发部位的治疗类型是生存和局部控制的重要决定因素。手术联合放疗是更好的治疗选择。
