Silva Edibaldo
Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, 984030 Nebraska Medical Center, Omaha, NE 68198, USA. Email:
World J Oncol. 2011 Jun;2(3):89-93. doi: 10.4021/wjon309w. Epub 2011 Jun 8.
The use of magnetic resonance imaging in the management of unselected female populations with early stage breast cancer has increased markedly over the past decade. Parallel to this trend many have observed an increased use of mastectomy over breast conservation due to concerns raised by the use of MRI. Similar concerns have led to the use of contra-lateral prophylactic mastectomy in patient populations not tested for potential genetic predisposition. These trends are difficult to understand as they divert from well established clinical paradigms which have been the result of widely accepted clinical research trials with more than three decades of clinical follow up. These trials have asserted that breast conserving surgery remains the accepted approach over mastectomy for the care of the patient with sporadic early stage breast cancer.
在过去十年中,磁共振成像在未经筛选的早期乳腺癌女性人群管理中的应用显著增加。与这一趋势并行的是,许多人观察到由于磁共振成像的使用引发的担忧,乳房切除术的使用相较于保乳手术有所增加。类似的担忧导致在未进行潜在遗传易感性检测的患者群体中使用对侧预防性乳房切除术。这些趋势难以理解,因为它们背离了已确立的临床范式,而这些范式是经过三十多年临床随访的广泛接受的临床研究试验的结果。这些试验断言,对于散发性早期乳腺癌患者的治疗,保乳手术仍是优于乳房切除术的公认方法。