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局部晚期皮肤鳞状细胞癌：顺铂、多西他赛序贯治疗及放疗取得显著疗效的两例病例报告

Locally Advanced Cutaneous Squamous Cell Carcinoma: Two Case Reports of Dramatic Responses to Sequential Cisplatin, Docetaxel and Radiotherapy.

作者信息

Dennis Kristopher E, Kim-Sing Charmaine, Laskin Janessa

机构信息

Radiation Oncology Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

出版信息

World J Oncol. 2011 Aug;2(4):199-203. doi: 10.4021/wjon328w. Epub 2011 Aug 24.

DOI:10.4021/wjon328w
PMID:29147248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5649659/
Abstract

Systemic therapy for cutaneous squamous cell carcinoma is typically reserved for rare cases of metastatic disease or lesions which cannot be adequately managed with local therapies. The relevant published literature is comprised only of case series and reports. Herein the authors present two cases of neglected locally advanced cutaneous squamous cell carcinoma not initially amenable to local therapies, which achieved dramatic partial responses to palliative Cisplatin and Docetaxel, facilitating sequential palliative radiotherapy. These reports add to the limited literature supporting the use of platinum-based therapy in locally advanced and metastatic cutaneous squamous cell carcinoma. They are the first describing the use of Cisplatin and Docetaxel in this setting.

摘要

皮肤鳞状细胞癌的全身治疗通常仅用于转移性疾病的罕见病例或无法通过局部治疗充分处理的病变。相关的已发表文献仅包括病例系列和报告。在此，作者介绍了两例被忽视的局部晚期皮肤鳞状细胞癌病例，这些病例最初无法接受局部治疗，但对姑息性顺铂和多西他赛治疗产生了显著的部分缓解，从而便于进行序贯姑息性放疗。这些报告补充了支持在局部晚期和转移性皮肤鳞状细胞癌中使用铂类治疗的有限文献。它们是首次描述在这种情况下使用顺铂和多西他赛的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/8de63ba2d5ac/wjon-02-199-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/d39861b1d9af/wjon-02-199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/896f9ed0a01b/wjon-02-199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/55da42af2229/wjon-02-199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/726f073b4a5a/wjon-02-199-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/84884378ecfb/wjon-02-199-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/8de63ba2d5ac/wjon-02-199-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/d39861b1d9af/wjon-02-199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/896f9ed0a01b/wjon-02-199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/55da42af2229/wjon-02-199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/726f073b4a5a/wjon-02-199-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/84884378ecfb/wjon-02-199-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/5649659/8de63ba2d5ac/wjon-02-199-g006.jpg

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