Taddei Graziano, Marzi Sara, Coletti Gino, De Paulis Danilo, Ricci Alessandro, Galzio Renato J
University of L'Aquila, Italy.
Division of Neurosurgery, S. Salvatore Hospital, L'Aquila, Italy.
World J Oncol. 2012 Apr;3(2):83-86. doi: 10.4021/wjon442w. Epub 2012 Apr 23.
It is rare for prostate carcinoma to metastasize to the central nervous system. It often represents a terminal event with death in one year frequently due to the advanced systemic disease. Starting by a case report, we also reviewed the relevant literature to focus on this uncommon entity from epidemiology to clinical manifestation and therapeutic strategies. In this article, a case of multiple brain prostate metastasis is reported and a review of relevant literature is also discussed. Treatments available for intracranial metastasis include neurosurgery, external beam radiation and hormonal manipulation. Surgery associated with whole brain radiotherapy seems to be effective in the control of brain lesions both relieving neurological symptoms and prolonging survival, even if prognosis remains dismal. From this case, we concluded that brain metastasis from prostate carcinoma is a rare, terminal event with death in one year frequently due to the advanced systemic disease. A better understanding of the biology of prostate carcinoma will help clarify the basis for its metastasis to the brain.
前列腺癌转移至中枢神经系统较为罕见。它通常代表着一种终末期事件，患者常因晚期全身性疾病在一年内死亡。我们从一则病例报告入手，还回顾了相关文献，以关注这个从流行病学、临床表现到治疗策略均不常见的实体。本文报告了一例前列腺癌多发脑转移病例，并讨论了相关文献综述。颅内转移的可用治疗方法包括神经外科手术、外照射放疗和激素治疗。手术联合全脑放疗似乎对控制脑转移灶有效，既能缓解神经症状又能延长生存期，即便预后依然不佳。从该病例中，我们得出结论，前列腺癌脑转移是一种罕见的终末期事件，患者常因晚期全身性疾病在一年内死亡。更好地了解前列腺癌生物学特性将有助于阐明其转移至脑部的基础。
