Salvati M, Frati A, Russo N, Brogna C, Piccirilli M, D'Andrea G, Occhiogrosso G, Pichierri A, Caroli E
Dept. of Neurological Sciences- Neurosurgery, Policlinico Umberto I University of Rome, La Sapienza, Rome, Italy.
J Exp Clin Cancer Res. 2005 Jun;24(2):203-7.
Brain metastasis from prostate carcinoma occurs very rarely. We describe 13 patients with single brain metastasis from prostatic cancer. Total removal of the lesions was performed in ten patients. Three patients underwent stereotactic biopsy. All patients were treated with postoperative whole brain radiotherapy (WBRT). Eight patients died for systemic disease after a mean time of 9.2 months with a diagnosis of metastasis. Five patients are still alive at 20, 14, 11, 7 and 6 months, respectively. Even if brain metastasis from prostate cancer is often a terminal event with death occurring within few months from diagnosis, we suggest the same protocol (surgery and/or radiosurgery plus postoperative WBRT) usually adopted to treat brain metastasis from other primitive tumours. A non specific neurological symptomatology and a possible normal dosage of serum specific antigen may contribute to a delay in diagnosis. However, considering the rarity of brain metastasis from prostate carcinoma, standard brain MRI follow-up in men with prostatic cancer does not seem to be necessary yet.
前列腺癌脑转移极为罕见。我们描述了13例前列腺癌单发脑转移患者。10例患者进行了病灶全切。3例患者接受了立体定向活检。所有患者术后均接受了全脑放疗（WBRT）。8例患者在诊断为转移后平均9.2个月死于全身性疾病。5例患者分别在20、14、11、7和6个月时仍存活。即使前列腺癌脑转移通常是一种终末期事件，诊断后数月内即会死亡，但我们建议采用通常用于治疗其他原发性肿瘤脑转移的相同方案（手术和/或放射外科手术加术后WBRT）。非特异性神经系统症状和血清特异性抗原可能的正常剂量可能导致诊断延迟。然而，考虑到前列腺癌脑转移的罕见性，对前列腺癌男性患者进行标准的脑部MRI随访目前似乎尚无必要。
