Miyazawa Tomonori, Koide Norihiko, Fujita Nobuhiro
Department of Surgery, Joetsu General Hospital, Joetsu, Japan.
World J Oncol. 2013 Feb;4(1):46-49. doi: 10.4021/wjon619w. Epub 2013 Mar 6.
This report presents a case of para-aortic and lateral pelvic lymph node recurrence of rectal cancer that showed complete response to S-1 monotherapy. A 69-year-old man underwent low anterior resection for rectal cancer in 2007. Para-aortic lymph and right lateral pelvic lymph node recurrence occurred in 2008. He received a fluorouracil/folinic acid plus oxaliplatin regimen; however, G4 neutropenia and G3 fatigue were experienced. We started S-1 monotherapy as a salvage treatment. Abdominal computed tomography did not reveal any para-aortic and lateral pelvic lymph nodes recurrence after 10 cycles of S-1 monotherapy. Hence, response in this case was classified as a complete response. No recurrence was noted 36 months after the complete response. S-1 monotherapy is likely to be effective in treating patients with metastatic colorectal cancer who do not respond to standard combination chemotherapy.
本报告介绍了一例直肠癌腹主动脉旁和盆腔外侧淋巴结复发患者，该患者对S-1单药治疗显示出完全缓解。一名69岁男性于2007年接受了直肠癌低位前切除术。2008年出现腹主动脉旁淋巴结和右侧盆腔外侧淋巴结复发。他接受了氟尿嘧啶/亚叶酸加奥沙利铂方案治疗；然而，出现了4级中性粒细胞减少和3级疲劳。我们开始使用S-1单药治疗作为挽救治疗。在进行10个周期的S-1单药治疗后，腹部计算机断层扫描未显示任何腹主动脉旁和盆腔外侧淋巴结复发。因此，该病例的反应被分类为完全缓解。完全缓解36个月后未观察到复发。S-1单药治疗可能对那些对标准联合化疗无反应的转移性结直肠癌患者有效。
