Akuzawa Nobuhiro, Hatori Takashi, Imai Kunihiko, Kitahara Yonosuke, Sakurai Shinji, Kurabayashi Masahiko
Department of Internal Medicine, Social Insurance Gunma Chuo General Hospital, 1-7-13 Koun-cho, Maebashi, Gunma 371-0025, Japan.
Department of Pathology, Social Insurance Gunma Chuo General Hospital, 1-7-13 Koun-cho, Maebashi, Gunma 371-0025, Japan.
World J Oncol. 2013 Oct;4(4-5):194-200. doi: 10.4021/wjon688w. Epub 2013 Sep 27.
A 96-year-old woman with a 5-year history of multiple myeloma was admitted to our hospital because of increasing fatigue and fever. Bone marrow plasma cell analysis showed t(11;14), del(13q), and del(17p13). Her condition deteriorated, and she developed plasmacytosis resembling plasma cell leukemia. Chromosome analysis showed trisomy of chromosome 8 in the circulating plasma cells. The plasmacytosis resolved spontaneously without chemotherapy after about 5 weeks, and the trisomy became undetectable. The findings suggest that trisomy 8 might have contributed to the transient plasmacytosis, and that chromosome 8 carries genes associated with plasma cell proliferation, maturation, and apoptosis.
一名患有多发性骨髓瘤5年的96岁女性因疲劳加重和发热入住我院。骨髓浆细胞分析显示存在t(11;14)、del(13q)和del(17p13)。她的病情恶化，出现了类似浆细胞白血病的浆细胞增多症。染色体分析显示循环浆细胞中存在8号染色体三体。约5周后，浆细胞增多症未经化疗自行缓解，且三体现象无法检测到。这些发现提示8号染色体三体可能导致了短暂的浆细胞增多症，且8号染色体携带与浆细胞增殖、成熟和凋亡相关的基因。
