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无放射学检测到原发灶的脑寡转移大细胞神经内分泌癌

Oligometastatic Large Cell Neuroendocrine Carcinoma of the Brain Without Radiologically Detected Primary.

作者信息

Suleiman Moyosore, Mullane Michael

机构信息

Department of Hematology and Oncology, John H Stroger Jr Hospital of Cook County, Chicago, IL 60612, USA.

出版信息

World J Oncol. 2014 Jun;5(3):135-138. doi: 10.14740/wjon805w. Epub 2014 Jun 25.

DOI:10.14740/wjon805w
PMID:29147392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5649817/
Abstract

A 60-year-old Polish male was admitted into our hospital with complaint of right-sided lower extremity weakness. CT of head showed a left frontal 2.6 × 1.5 cm mass. Staging work-up did not show any other associated lesions in the chest or abdomen. Brain tumor was resected with histology consistent with large cell neuroendocrine carcinoma with most likely lung primary because of TTF-1 positivity. Following recovery from surgery, he had external beam radiation therapy to the brain and systemic chemotherapy with four cycles of cisplatin/etoposide. Patient is alive and doing well 6 months post diagnosis with no evidence of recurrence.

摘要

一名60岁的波兰男性因右侧下肢无力入院。头部CT显示左额叶有一个2.6×1.5厘米的肿块。分期检查未发现胸部或腹部有任何其他相关病变。脑肿瘤被切除，组织学检查结果与大细胞神经内分泌癌一致，由于TTF-1呈阳性，最可能原发于肺部。手术后康复后，他接受了脑部的外照射放疗以及四个周期的顺铂/依托泊苷全身化疗。患者在确诊后6个月仍然存活且状况良好，没有复发迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c3/5649817/1b9ed17a18b0/wjon-05-135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c3/5649817/564664b78684/wjon-05-135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c3/5649817/541a6d196e4b/wjon-05-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c3/5649817/1b9ed17a18b0/wjon-05-135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c3/5649817/564664b78684/wjon-05-135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c3/5649817/541a6d196e4b/wjon-05-135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c3/5649817/1b9ed17a18b0/wjon-05-135-g003.jpg

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[A case of gastric large cell neuroendocrine carcinoma (LCNEC) for whom chemotherapy of CDDP+CPT-11 proved very effective].一例胃大细胞神经内分泌癌（LCNEC）患者，顺铂+伊立替康化疗对其疗效显著
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Small cell carcinoma of the brain without extracranial involvement by serial CT, MRI and PET.经系列CT、MRI和PET检查证实的无颅外转移的脑小细胞癌
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High-grade neuroendocrine carcinoma of the lung: comparative clinicopathological study of large cell neuroendocrine carcinoma and small cell lung carcinoma.肺高级别神经内分泌癌：大细胞神经内分泌癌与小细胞肺癌的临床病理对照研究
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Neuroendocrine carcinoma of unknown primary site.原发部位不明的神经内分泌癌。
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9
Extrapulmonary small cell carcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans.肺外小细胞癌：经系列PET/CT扫描显示脑部受累，而颅外无恶性肿瘤证据。
World J Surg Oncol. 2008 Sep 25;6:102. doi: 10.1186/1477-7819-6-102.
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One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.“类癌”百年之后：美国35825例神经内分泌肿瘤的流行病学及预后因素
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