Neurology Department, School of Medicine, Acıbadem University, Ic Erenkoy Mah. Kerem Aydınlar Kampusu. Kayısdag Cad., 34752, Atasehir/Istanbul, Turkey.
Faculty of Medicine, Psychiatry Department, Dokuz Eylul University, Kultur Mah. Cumhuriyet Blv. No: 144, 35220, Konak/Izmır, Turkey.
Acta Neurol Belg. 2020 Aug;120(4):837-844. doi: 10.1007/s13760-017-0856-x. Epub 2017 Nov 16.
The co-existence of psychiatric comorbidities with migraine is well known; however, the relationship between alexithymia and migraine has not been persuasively shown yet. The aim of the study was to assess the relationships between migraine-related disability, depression, anxiety and alexithymia. One hundred and forty-five migraine patients (33.18 ± 8.6; 111 females, 34 males), and 50 control subjects (29.06 ± 7.6; 34 females, 16 males) were prospectively enrolled for the study. The participants completed a demographic data form and Migraine Disability Assessment Scale, Beck Depression Inventory, Beck Anxiety Inventory and Toronto Alexithymia Score-20 (TAS-20). All migraine patients were more depressive (p = 0.01) and anxious (p = 0.001) than the healthy subjects. TAS-20 scores of the migraine sufferers and the control group did not indicate alexithymia. The migraine-related disability of all migraine patients was severe (27.84 ± 29.22). Depression and anxiety scores in the migraine patients were highly correlated with each other and TAS-20 (r = 0.485, p = 0.001) and all its subscales in turn: difficulty in identifying (r = 0.435, p < 0.001) and describing feelings (r = 0.451, p = 0.001) and externally oriented thinking (r = 0.302, p = 0.001). Moreover, logistic regression analysis revealed that depression and anxiety predicted alexithymia. Our findings showed a complex relationship between migraine, depression, anxiety and alexithymia. On the other hand, alexithymia apparently was not directly connected to migraine, but its presence could be predicted in migraine patients because of co-morbid depression and anxiety.
精神共病与偏头痛共存是众所周知的；然而，述情障碍与偏头痛之间的关系尚未得到令人信服的证明。本研究旨在评估偏头痛相关残疾、抑郁、焦虑和述情障碍之间的关系。145 名偏头痛患者（33.18±8.6；111 名女性，34 名男性）和 50 名对照受试者（29.06±7.6；34 名女性，16 名男性）前瞻性入组研究。参与者完成了一份人口统计学数据表格和偏头痛残疾评估量表、贝克抑郁量表、贝克焦虑量表和多伦多述情障碍量表-20（TAS-20）。所有偏头痛患者的抑郁（p=0.01）和焦虑（p=0.001）评分均高于健康受试者。偏头痛患者和对照组的 TAS-20 评分均未显示述情障碍。所有偏头痛患者的偏头痛相关残疾均为重度（27.84±29.22）。偏头痛患者的抑郁和焦虑评分彼此高度相关，并且与 TAS-20（r=0.485，p=0.001）及其所有子量表（依次为：难以识别（r=0.435，p<0.001）和描述感受（r=0.451，p=0.001）和外向思维（r=0.302，p=0.001））相关。此外，逻辑回归分析显示抑郁和焦虑预测述情障碍。我们的研究结果表明偏头痛、抑郁、焦虑和述情障碍之间存在复杂的关系。另一方面，述情障碍显然与偏头痛没有直接关系，但由于共病抑郁和焦虑，偏头痛患者中述情障碍的存在可以预测。
