Sahin Aysenur, Cakir Seda, Ilgaz Aydinlar Elif, Ertas Mustafa, Yalınay Dikmen Pınar
Department of Neurology, Faculty of Medicine, Acibadem University School of Medicine, Istanbul, Türkiye.
Department of Neurology, Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Front Neurol. 2025 Jul 16;16:1545520. doi: 10.3389/fneur.2025.1545520. eCollection 2025.
This study aimed to investigate the prevalence and symptom severity of misophonia among individuals with migraine, and to explore its clinical and psychological correlates.
Misophonia is a neurobehavioral condition characterized by intense emotional and physiological reactions to specific everyday sounds, such as chewing or tapping. Although misophonia has been associated with increased sensory sensitivity and psychiatric comorbidities, its relationship with other sensory processing disorders-particularly migraine-remains underexplored.
In this cross-sectional study, 205 migraine patients and 205 healthy controls completed validated scales assessing misophonia symptoms, psychiatric comorbidities, and migraine-related disability. Statistical comparisons and univariate linear regression analyses were performed to identify predictors of misophonia.
Our findings revealed a significantly higher prevalence of misophonia among individuals with migraine compared to healthy controls (44.9% vs. 17.6%). Misophonia symptoms were not only more common but also more severe in the migraine group. Migraine patients with comorbid misophonia scored significantly higher on the Headache Impact Test-6 and all components of the Migraine Disability Assessment Scale compared to those without misophonia. Sensory sensitivities such as photophobia, phonophobia, osmophobia, and allodynia were also more frequent and intense among migraine patients with misophonia. Furthermore, these patients exhibited significantly higher levels of anxiety, stress, and obsessive-compulsive symptoms. Regression analyses revealed that stress, obsessive-compulsive symptoms, allodynia, and migraine-related disability were significant predictors of misophonia scores.
Misophonia is a common and clinically significant comorbidity in migraine, associated with heightened sensory sensitivities, increased psychiatric burden, and greater functional impairment. The co-occurrence of these conditions may be underpinned by shared neurobiological mechanisms, particularly networks mediating sensory-emotional integration. Further longitudinal and neurobiological research is warranted to clarify causal relationships and inform targeted interventions.
本研究旨在调查偏头痛患者中恐音症的患病率及症状严重程度，并探讨其临床和心理相关因素。
恐音症是一种神经行为状况，其特征为对特定日常声音（如咀嚼或轻敲声）产生强烈的情绪和生理反应。尽管恐音症与感觉敏感性增加和精神疾病共病有关，但其与其他感觉处理障碍（尤其是偏头痛）的关系仍未得到充分研究。
在这项横断面研究中，205名偏头痛患者和205名健康对照完成了评估恐音症症状、精神疾病共病和偏头痛相关残疾的有效量表。进行了统计比较和单变量线性回归分析以确定恐音症的预测因素。
我们的研究结果显示，与健康对照相比，偏头痛患者中恐音症的患病率显著更高（44.9%对17.6%）。恐音症症状在偏头痛组中不仅更常见，而且更严重。与无恐音症的偏头痛患者相比，合并恐音症的偏头痛患者在头痛影响测试-6和偏头痛残疾评估量表的所有分量表上得分显著更高。在合并恐音症的偏头痛患者中，畏光、畏声、嗅觉过敏和痛觉过敏等感觉敏感性也更频繁且更强烈。此外，这些患者表现出显著更高水平的焦虑、压力和强迫症状。回归分析显示，压力、强迫症状、痛觉过敏和偏头痛相关残疾是恐音症得分的显著预测因素。
恐音症是偏头痛中一种常见且具有临床意义的共病，与感觉敏感性增强、精神负担增加和功能损害加重有关。这些情况的共同出现可能由共同的神经生物学机制支撑，特别是介导感觉-情绪整合的神经网络。有必要进行进一步的纵向和神经生物学研究以阐明因果关系并为有针对性的干预提供依据。
