Liang Jun, Xu Ya-Yun, Zhang Cheng, Xia Qing-Rong
1 Department of Pharmacy, Hefei Fourth People's Hospital, Hefei - PR China.
2 Anhui Mental Health Center, Hefei - PR China.
Int J Biol Markers. 2018 May;33(2):174-179. doi: 10.5301/ijbm.5000313. Epub 2017 Sep 11.
Previous studies have revealed a conflicting relationship of xeroderma pigmentosum group G (XPG) gene polymorphism with gastric cancer (GC) risk. To our knowledge, this is the first meta-analysis to investigate the association between rs751402 mutation located on the XPG promoter region and GC risk.
We undertook a meta-analysis by identifying relevant articles from the PubMed, Web of Science and China National Knowledge Infrastructure (CNKI) databases on February 28, 2017. By pooling 9 eligible studies, 3,539 GC cases and 3,948 controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using the fixed-effects or random-effects model depending on the existence of heterogeneity across studies. The population attributable risk (PAR%) was estimated to better understand the public health risk.
All included studies had been conducted in China. Significant associations were found between the XPG rs751402 polymorphism and the risk of GC (TT vs. CC: OR = 1.43, 95% CI, 1.11-1.84; CT vs. CC: OR = 1.15, 95% CI, 1.04-1.26; dominant model: OR = 1.17, 95% CI, 1.07-1.29; recessive model: OR = 1.30, 95% CI, 1.05-1.62; T vs. C: OR = 1.18, 95% CI, 1.06-1.32). The estimated PAR% was about 4.9%-8.8%. Funnel plots did not reveal any potential publication bias. The sensitivity analyses showed that the results were relatively robust.
This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for GC in the Chinese population.
既往研究揭示了着色性干皮病G组（XPG）基因多态性与胃癌（GC）风险之间存在相互矛盾的关系。据我们所知，这是第一项调查位于XPG启动子区域的rs751402突变与GC风险之间关联的荟萃分析。
2017年2月28日，我们通过检索PubMed、Web of Science和中国知网（CNKI）数据库来识别相关文章，进行了一项荟萃分析。通过汇总9项符合条件的研究，纳入了3539例GC病例和3948例对照。根据各研究间异质性的存在情况，使用固定效应或随机效应模型计算合并比值比（OR）及95%置信区间（95%CI）。估计人群归因风险（PAR%）以更好地了解公共卫生风险。
所有纳入研究均在中国进行。发现XPG rs751402多态性与GC风险之间存在显著关联（TT与CC比较：OR = 1.43，95%CI为1.11 - 1.84；CT与CC比较：OR = 1.15，95%CI为1.04 - 1.26；显性模型：OR = 1.17，95%CI为1.07 - 1.29；隐性模型：OR = 1.30，95%CI为1.05 - 1.62；T与C比较：OR = 1.18，95%CI为1.06 - 1.32）。估计的PAR%约为4.9% - 8.8%。漏斗图未显示任何潜在的发表偏倚。敏感性分析表明结果相对稳健。
这项荟萃分析表明，XPG rs751402多态性可能是中国人群GC的一个风险因素。
