Su Yanyan, Yang Chong, Zhang Zongxiang
Department of General Surgery, Hangzhou Red Cross Hospital/Zhe Jiang Chinese Medicine and Western Medicine Integrated Hospital , Hangzhou, China .
Genet Test Mol Biomarkers. 2017 Oct;21(10):619-624. doi: 10.1089/gtmb.2017.0056. Epub 2017 Aug 23.
Studies exploring the association between the Xeroderma pigmentosum group G (XPG) gene polymorphisms and gastric cancer (GC) risk provide conflicting findings. Thus, this meta-analysis was performed.
The PubMed and EMBASE databases were comprehensively searched to identify studies for the inclusion in the meta-analysis. The strength of the association was evaluated by calculating pooled odds ratios and 95% confidence intervals.
Nine case-control studies involving 3540 cases and 3953 controls were included in the meta-analysis, which revealed that the XPG rs751402 polymorphism is positively associated with GC risk and could be viewed as a risk factor of GC in three genetic models.
The XPG gene rs751402 polymorphism is associated with an increased risk of GC in Chinese Han populations. This finding should be verified by larger studies that include additional ethnic groups.
探索着色性干皮病G组（XPG）基因多态性与胃癌（GC）风险之间关联的研究结果相互矛盾。因此，进行了这项荟萃分析。
全面检索了PubMed和EMBASE数据库，以确定纳入荟萃分析的研究。通过计算合并比值比和95%置信区间来评估关联强度。
荟萃分析纳入了9项病例对照研究，共3540例病例和3953例对照，结果显示XPG rs751402多态性与GC风险呈正相关，在三种遗传模型中可被视为GC的一个风险因素。
XPG基因rs751402多态性与中国汉族人群GC风险增加有关。这一发现应通过纳入更多种族群体的更大规模研究来验证。
