Betsch Léo, Savarin Julie, Bendahmane Mohammed, Szecsi Judit
Laboratoire Reproduction et Développement des Plantes, Univ Lyon, ENS de Lyon, Université Claude Bernard Lyon 1, CNRS, INRA, 69342, Lyon, France.
Results Probl Cell Differ. 2017;64:149-172. doi: 10.1007/978-3-319-67591-6_7.
The Translationally Controlled Tumor Protein (TCTP) is a conserved protein which expression was associated with several biochemical and cellular functions. Loss-of-function mutants are lethal both in animals and in plants, making the identification of its exact role difficult. Recent data using the model plant Arabidopsis thaliana provided the first viable adult knockout for TCTP and helped addressing the biological role of TCTP during organ development and the functional conservation between plants and animals. This chapter summarizes our up to date knowledge about the role of TCTP in plants and discuss about conserved functions and mechanisms between plants and animals.
翻译调控肿瘤蛋白(TCTP)是一种保守蛋白,其表达与多种生化和细胞功能相关。功能缺失突变体在动物和植物中均具有致死性,这使得确定其确切作用变得困难。最近利用模式植物拟南芥获得的数据首次实现了TCTP在成年植株中的可行敲除,并有助于阐明TCTP在器官发育过程中的生物学作用以及植物与动物之间的功能保守性。本章总结了我们目前关于TCTP在植物中作用的知识,并讨论了植物与动物之间的保守功能和机制。